Molecular Biology of the Cell Call for Nominations: MBC Editor-in-Chief

Home Help [Feedback] [For Subscribers] [Archive] [Search] --
QUICK SEARCH:   [advanced]


     

MBC in Press, published online ahead of print January 10, 2007
Mol. Biol. Cell 10.1091/mbc.E06-09-0802

A more recent version of this article appeared on March 1, 2007
This Article
Right arrow Full Text (PDF)
Right arrow Supplemental Material
Right arrow All Versions of this Article:
E06-09-0802v1
18/3/1064    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Liao, H.-J.
Right arrow Articles by Carpenter, G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Liao, H.-J.
Right arrow Articles by Carpenter, G.

Submitted on September 8, 2006
Revised on December 15, 2006
Accepted on January 2, 2007

Role of the Sec61 Translocon in EGF Receptor Trafficking to the Nucleus and Gene Expression

Hong-Jun Liao and Graham Carpenter

Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232-0146

Monitoring Editor: Sandra Schmid

The EGF-dependent trafficking of the intact EGF receptor to the nucleus and its requirement for growth factor induction of cyclin D and other genes has been reported. Unresolved is the mechanism by which this or other transmembrane proteins are excised from a lipid bilayer before nuclear translocalization. We report that, following the addition of EGF, the cell surface EGF receptor is trafficked to the ER where it associates with Sec61{beta}, a component of the Sec61 translocon, and is retrotranslocated from the ER to the cytoplasm. Abrogation of Sec61{beta} expression prevents EGF-dependent localization of EGF receptors to the nucleus and expression of cyclin D. This indicates that EGF receptors are trafficked from the ER to the nucleus by a novel pathway that involves the Sec61 translocon.

Address correspondence to: Graham Carpenter (graham.carpenter{at}vanderbilt.edu)




This article has been cited by other articles:


Home page
 J. Immunol.Home page
A. De Filippo, R. J. Binder, C. Camisaschi, V. Beretta, F. Arienti, A. Villa, P. Della Mina, G. Parmiani, L. Rivoltini, and C. Castelli
Human Plasmacytoid Dendritic Cells Interact with gp96 via CD91 and Regulate Inflammatory Responses
J. Immunol., November 1, 2008; 181(9): 6525 - 6535.
[Abstract] [Full Text] [PDF]

Home page
 Sci SignalHome page
S. M. Swanson and J. J. Kopchick
Nuclear Localization of Growth Hormone Receptor: Another Age of Discovery for Cytokine Action?
Sci. Signal., December 4, 2007; 2007(415): pe69 - pe69.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S.-C. Hsu and M.-C. Hung
Characterization of a Novel Tripartite Nuclear Localization Sequence in the EGFR Family
J. Biol. Chem., April 6, 2007; 282(14): 10432 - 10440.
[Abstract] [Full Text] [PDF]


Home Help [Feedback] [For Subscribers] [Archive] [Search] --
Copyright © 2007 by The American Society for Cell Biology. Terms of copyright protection, warranties, and disclaimers.