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MBC in Press, published online ahead of print October 24, 2007
Mol. Biol. Cell 10.1091/mbc.E07-06-0528

A more recent version of this article appeared on January 1, 2008
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Submitted on June 5, 2007
Revised on September 10, 2007
Accepted on October 17, 2007

Chromatin Challenges during DNA Replication: A Systems Representation

Kurt W. Kohn, Mirit I. Aladjem, John N. Weinstein, and Yves Pommier

Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892

Monitoring Editor: Gerard Evan

In a recent review, Groth et al. (Groth et al., 2007) presented a comprehensive account of nucleosome disassembly in front of a DNA replication fork, assembly behind the replication fork, and the copying of epigenetic information onto the replicated chromatin. Understanding those processes however would be enhanced by a comprehensive graphical depiction analogous to a circuit diagram. Accordingly, we have constructed a molecular interaction map (MIM) (Kohn et al., 2006b) that preserves in essentially complete detail the processes described by Groth et al. The MIM organizes and elucidates the information presented by Groth et al. on the complexities of chromatin replication, thereby providing a tool for system-level comprehension of the effects of genetic mutations, altered gene expression, and pharmacologic intervention.

Address correspondence to: Kurt W. Kohn (kohnk{at}dc37a.nci.nih.gov)






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