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MBC in Press, published online ahead of print February 27, 2008
Mol. Biol. Cell 10.1091/mbc.E07-09-0914

A more recent version of this article appeared on May 1, 2008
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Submitted on September 18, 2007
Revised on January 2, 2008
Accepted on February 19, 2008

Multiplexed Dendritic Targeting of {alpha}CaMKII, NG and ARC RNAs by the A2 Pathway

Yuanzheng Gao,*{dagger} Vedakumar Tatavarty,*{dagger} George Korza,{ddagger} Mikhail K. Levin,{ddagger}{sect} and John H. Carson{ddagger}{sect}

{dagger}Neuroscience Program, {ddagger}Department of Molecular Microbial and Structural Biology; {sect}Richard Berlin Center for Cell Analysis and Modeling, University of Connecticut Health Center, Farmington CT 06030

Monitoring Editor: Karsten Weis

In neurons many different RNAs are targeted to dendrites where local expression of the encoded proteins mediates synaptic plasticity during learning and memory. It is not known if each RNA follows a separate trafficking pathway or if multiple RNAs are targeted to dendrites by the same pathway. Here we show that RNAs encoding {alpha} calcium calmodulin-dependent protein kinase II ({alpha}CaMKII), neurogranin (NG) and activity regulated cytoskeleton associated protein (ARC) are coassembled into the same RNA granules and targeted to dendrites by the same cis/trans determinants (hnRNP A2 response element (A2RE) and hnRNP A2), that mediate dendritic targeting of myelin basic protein RNA by the A2 pathway in oligodendrocytes. Multiplexed dendritic targeting of different RNAs by the same pathway represents a new organizing principle for coordinating gene expression at the synapse.

*These authors contributed equally to this work.

Address correspondence to: John H. Carson (jcarson{at}nso2.uchc.edu)






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