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MBC in Press, published online ahead of print October 15, 2008
Mol. Biol. Cell 10.1091/mbc.E08-05-0517

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Submitted on May 23, 2008
Revised on September 24, 2008
Accepted on October 2, 2008

Lipid Microdomains in Cell Nucleus

Giacomo Cascianelli,* Maristella Villani,* Marcello Tosti,{dagger} Francesca Marini,* Elisa Bartoccini,* Mariapia Viola Magni,* and Elisabetta Albi*

*Department of Clinical and Experimental Medicine, Physiopathology Section, University School of Medicine, University of Perugia, Policlinico Monteluce, 06100 Perugia, Italy; {dagger}Dipartimento di Scienze Biopatologiche ed Igiene delle Produzioni Animali e Alimentari, University of Perugia, 06126 Perugia Italy

Monitoring Editor: Karsten Weis

It is known that nuclear lipids play a role in proliferation, differentiation and apoptotic process. Cellular nuclei contain high levels of phosphatidylcholine and sphingomyelin which are partially linked with cholesterol and proteins to form lipid-protein complexes. These lipids are also associated with transcription factors and newly synthesized RNA but, up to date, their organization is still unknown. The aim of the present work was to study if these specific lipid-protein interactions could be nuclear membrane microdomains and to evaluate their possible role. The results obtained demonstrate for the first time the existence of nuclear microdomains characterized by a specific lipid composition similar to that of intranuclear lipid-protein complexes previously described. Nuclear microdomain lipid composition changes during cell proliferation when the content of newly synthesized RNA increases. Because previous data show a correlation between nuclear lipids and transcription process, the role of nuclear microdomains in cellular functions is discussed.

Address correspondence to: Elisabetta Albi (ealbi{at}unipg.it)




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