Figure 1.   Schematic representation of adaptins and related proteins (A) and of the trafficking pathways in which they might be involved (B). The scheme in A depicts the structure of a generic AP complex, a GGA, and a stonin. N and C indicate the amino- and carboxy-termini of the proteins, respectively. GAE, -adaptin ear-homology domain; GAT, GGA, and TOM1-homology domain; MHD, µ-homology domain; PRD, proline-rich domain; SHD, stonin-homology domain; VHS, Vps27p/HRS/STAM-homology domain. B is a scheme of postGolgi trafficking pathways, showing the putative localization and role AP complexes, GGAs, and stonins within the cell. Of these, only the localization and role of AP-2 have been established with certainty. All the others should be considered tentative.

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