Septins, under Cla4p Regulation, and the Chitin Ring Are Required for Neck Integrity in Budding Yeast
Mol. Biol. Cell
Schmidt et al. 10.1091/mbc.E02-08-0547.
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Scheme 1 -
Scheme 1. Proposed effect of Cla4p and Chs3p on septin anchoring and organization. Cla4p helps anchoring of the septin ring at the neck. The septin ring, in turn, localizes Chs3p at the neck through binding of Bni4p and Chs4p as intermediaries (DeMarini et al., 1997). Both septins and the chitin ring, dependent on Chs3p activity, cooperate in preventing growth at the neck. When either the septins or Chs3p are defective, not much change in neck growth is noted. If both are faulty, however, neck growth becomes unrestrained, which contributes further to septin disorganization (curved arrow).