Supplemental Material

This article contains the following supporting material:

• Supplemental Figure 1 - Multiple sequence alignments of the RPB5 and RPB6 sequence families. These alignments were used to infer the sequence family trees and also to homology model the different trypanosome subunits.
• Supplemental Figure 2 - Effect of RNAi on growth. A) TbRPB6-RNAi in bloodstream froms B) TbRPB6z-RNAi in bloodstream forms. C) TbRPB6-RNAi in Tsetse froms D) TbRPB6z-RNAi in Tsetse forms.
• Supplemental Figure 3 - Mass spectrometry peptide match data.
• Supplemental Figure 4 - Genome database and gene model source information.