![[Feedback]](/icons/banner/feedbackACT.gif){kind=icon}
![[For Subscribers]](/icons/banner/subscriberACT.gif){kind=icon}
![[Archive]](/icons/banner/archiveACT.gif){kind=icon}
![[Search]](/icons/banner/searchACT.gif){kind=icon}
|
|
|
|
|
||
A more recent version of this article appeared on February 1, 2002
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Submitted on June 21, 2001
Revised on October 12, 2001
Accepted on November 2, 2001
1 Department of Biology, University of Pennsylvania, Philadelphia, PA 19104
2 Division of Geographic Medicine, University of Alabama, Birmingham, AL 35294
3 Department of Biology, University of Pennsylvania, Philadelphia, PA 19104; and Center for Tropical and Emerging Global Diseases, and Department of Cellular Biology, University of Georgia, Athens, GA 30602
4 Department of Biology, 305 Goddard Laboratories, University of Pennsylvania, Philadelphia, PA, 19104
5 Department of Cell and Developmental Biology, University of Pennsylvania, Philadelphia, PA 19104
* Corresponding author. E-mail address: droos{at}mail.sas.upenn.edu.
The phylum apicomplexa includes thousands of species of obligate intracellular parasites, many of which are significant human and/or animal pathogens. Parasites in this phylum replicate by assembling daughters within the mother, using a cytoskeletal and membranous scaffolding termed the inner membrane complex. Most apicomplexan parasites, including Plasmodium sp. (which cause malaria), package many daughters within a single mother during mitosis, whereas Toxoplasma gondii typically packages only two. The comparatively simple pattern of T. gondii cell division, combined with its molecular genetic and cell biological accessibility, makes this an ideal system to study parasite cell division. A recombinant fusion between the fluorescent protein reporter YFP and the inner membrane complex protein IMC1 has been exploited to examine daughter scaffold formation in T. gondii. Time-lapse video microscopy permits the entire cell cycle of these parasites to be visualized in vivo. In addition to replication via endodyogeny (packaging two parasites at a time), T. gondii is also capable of forming multiple daughters, suggesting fundamental similarities between cell division in T. gondii and other apicomplexan parasites.
This article has been cited by other articles:
|
|
 |
|
  J. L. Gordon, W. L. Beatty, and L. D. Sibley A Novel Actin-Related Protein Is Associated with Daughter Cell Formation in Toxoplasma gondii Eukaryot. Cell, September 1, 2008; 7(9): 1500 - 1512. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Nishi, K. Hu, J. M. Murray, and D. S. Roos Organellar dynamics during the cell cycle of Toxoplasma gondii J. Cell Sci., May 1, 2008; 121(9): 1559 - 1568. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. J. P. Ferguson, N. Sahoo, R. A. Pinches, J. M. Bumstead, F. M. Tomley, and M.-J. Gubbels MORN1 Has a Conserved Role in Asexual and Sexual Development across the Apicomplexa Eukaryot. Cell, April 1, 2008; 7(4): 698 - 711. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Suda, H. Nakanishi, E. M. Mathieson, and A. M. Neiman Alternative Modes of Organellar Segregation during Sporulation in Saccharomyces cerevisiae Eukaryot. Cell, November 1, 2007; 6(11): 2009 - 2017. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. F. Sautel, D. Cannella, O. Bastien, S. Kieffer, D. Aldebert, J. Garin, I. Tardieux, H. Belrhali, and M.-A. Hakimi SET8-Mediated Methylations of Histone H4 Lysine 20 Mark Silent Heterochromatic Domains in Apicomplexan Genomes Mol. Cell. Biol., August 15, 2007; 27(16): 5711 - 5724. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. D. Gilk, Y. Raviv, K. Hu, J. M. Murray, C. J. M. Beckers, and G. E. Ward Identification of PhIL1, a Novel Cytoskeletal Protein of the Toxoplasma gondii Pellicle, through Photosensitized Labeling with 5-[125I]Iodonaphthalene-1-Azide. Eukaryot. Cell, October 1, 2006; 5(10): 1622 - 1634. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M.-J. Gubbels, S. Vaishnava, N. Boot, J.-F. Dubremetz, and B. Striepen A MORN-repeat protein is a dynamic component of the Toxoplasma gondii cell division apparatus J. Cell Sci., June 1, 2006; 119(11): 2236 - 2245. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Chaudhary, R. G. K. Donald, M. Nishi, D. Carter, B. Ullman, and D. S. Roos Differential Localization of Alternatively Spliced Hypoxanthine-Xanthine-Guanine Phosphoribosyltransferase Isoforms in Toxoplasma gondii J. Biol. Chem., June 10, 2005; 280(23): 22053 - 22059. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. K. Howe, R. Y. Gaji, M. Mroz-Barrett, M.-J. Gubbels, B. Striepen, and S. Stamper Sarcocystis neurona Merozoites Express a Family of Immunogenic Surface Antigens That Are Orthologues of the Toxoplasma gondii Surface Antigens (SAGs) and SAG-Related Sequences Infect. Immun., February 1, 2005; 73(2): 1023 - 1033. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. L. Pfluger, H. V. Goodson, J. M. Moran, C. J. Ruggiero, X. Ye, K. M. Emmons, and K. M. Hager Receptor for Retrograde Transport in the Apicomplexan Parasite Toxoplasma gondii Eukaryot. Cell, February 1, 2005; 4(2): 432 - 442. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. I. Khater, R. E. Sinden, and J. T. Dessens A malaria membrane skeletal protein is essential for normal morphogenesis, motility, and infectivity of sporozoites J. Cell Biol., November 8, 2004; 167(3): 425 - 432. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Hu, D. S. Roos, S. O. Angel, and J. M. Murray Variability and heritability of cell division pathways in Toxoplasma gondii J. Cell Sci., November 1, 2004; 117(23): 5697 - 5705. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Dzierszinski, M. Nishi, L. Ouko, and D. S. Roos Dynamics of Toxoplasma gondii Differentiation Eukaryot. Cell, August 1, 2004; 3(4): 992 - 1003. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Arrizabalaga, F. Ruiz, S. Moreno, and J. C. Boothroyd Ionophore-resistant mutant of Toxoplasma gondii reveals involvement of a sodium/hydrogen exchanger in calcium regulation J. Cell Biol., June 7, 2004; 165(5): 653 - 662. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Gaskins, S. Gilk, N. DeVore, T. Mann, G. Ward, and C. Beckers Identification of the membrane receptor of a class XIV myosin in Toxoplasma gondii J. Cell Biol., May 10, 2004; 165(3): 383 - 393. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. T. Stedman, A. R. Sussmann, and K. A. Joiner Toxoplasma gondii Rab6 Mediates a Retrograde Pathway for Sorting of Constitutively Secreted Proteins to the Golgi Complex J. Biol. Chem., February 7, 2003; 278(7): 5433 - 5443. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M.-J. Gubbels, C. Li, and B. Striepen High-Throughput Growth Assay for Toxoplasma gondii Using Yellow Fluorescent Protein Antimicrob. Agents Chemother., January 1, 2003; 47(1): 309 - 316. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Mann, E. Gaskins, and C. Beckers Proteolytic Processing of TgIMC1 during Maturation of the Membrane Skeleton of Toxoplasma gondii J. Biol. Chem., October 18, 2002; 277(43): 41240 - 41246. [Abstract] [Full Text] [PDF]
|
|
