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A more recent version of this article appeared on January 1, 2002
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Submitted on July 26, 2001
Revised on October 4, 2001
Accepted on October 10, 2001
1 Department of Biological Chemistry, University of California Los Angeles School of Medicine, Los Angeles, California
2 Ahmanson Center for Advanced EM and Imaging, House Ear Institute, Los Angeles, California
3 Institute for Pure and Applied Mathematics, University of California at Los Angeles, Los Angeles, California (present address: Department of Biostatistics, Harvard University, Boston, Massachusetts)
4 Department of Chemistry, The Scripps Research Institute, La Jolla, California
* Corresponding author. E-mail address: dimeyer{at}ucla.edu.
Expression of the 180-kD canine ribosome receptor in Saccharomyces cerevisiae leads to the accumulation of ER-like membranes. Gene expression patterns in strains expressing various forms of p180, each of which gives rise to unique membrane morphologies, were surveyed by microarray analysis. Several genes whose products regulate phospholipid biosynthesis were determined by Northern blotting to be differentially expressed in all strains that undergo membrane proliferation. Of these, the INO2 gene product was found to be essential for formation of p180-inducible membranes. Expression of p180 in ino2delta cells failed to give rise to the p180-induced membrane proliferation seen in wild-type cells, whereas p180 expression in ino4delta cells gave rise to membranes indistinguishable from wild type. Thus, Ino2p is required for the formation of p180-induced membranes, and, in this case, appears to be functional in the absence of its putative binding partner, Ino4p.
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