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A more recent version of this article appeared on September 1, 2002
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Submitted on December 10, 2001
Revised on June 5, 2002
Accepted on June 20, 2002
1 Howard Hughes Medical Institute and the Department of Cell Biology, Yale University School of Medicine, New Haven, CT
* Corresponding author. E-mail address: susan.ferronovick{at}yale.edu.
Ypt1p regulates vesicle tethering and fusion events from the ER to the Golgi and through the early Golgi. Genetic studies have suggested a functional relationship between Ypt1p and Ypt31p/Ypt32p. Ypt31p and Ypt32p are a pair of functionally redundant GTPases that act after Ypt1p to mediate intra-Golgi traffic or the budding of post-Golgi vesicles from the trans-Golgi. Here we report that a novel Ypt32p exchange factor is a putative effector of Ypt1p. These findings implicate small GTP-binding proteins of the Ypt/Rab family in a signal cascade that directs membrane traffic through the secretory pathway.
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