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A more recent version of this article appeared on May 1, 2002
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Submitted on October 3, 2001
Revised on January 18, 2002
Accepted on February 1, 2002
1 Howard Hughes Medical Institute and Division of Biology, California Institute of Technology, Pasadena, CA 91125 USA
* Corresponding author. E-mail address: pws{at}caltech.edu.
Ovulation in Caenorhabditis elegans requires IP3 signaling activated by the EGF-receptor homolog LET-23. We generated a deletion mutant of a type I 5-phosphatase, ipp-5, and find a novel ovulation phenotype whereby the spermatheca hyperextends to engulf two oocytes per ovulation cycle. The temporal and spatial expression of IPP-5 is consistent with its proposed inhibition of IP3 signaling in the adult spermatheca. ipp-5 acts downstream of let-23, and interacts with let-23-mediated IP3 signaling pathway genes. We infer that IPP-5 negatively regulates IP3 signaling to ensure proper spermathecal contraction.
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