![[Feedback]](/icons/banner/feedbackACT.gif){kind=icon}
![[For Subscribers]](/icons/banner/subscriberACT.gif){kind=icon}
![[Archive]](/icons/banner/archiveACT.gif){kind=icon}
![[Search]](/icons/banner/searchACT.gif){kind=icon}
![[Contents]](/icons/banner/tocACT.gif){kind=icon}
|
|
|
|
|
||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Vol. 13, Issue 2, 503-514, February 2002
and
§
Departments of *Molecular Biophysics and Biochemistry and
Protein kinases in the Cot-1/Orb6/Ndr/Warts family are important
regulators of cell morphogenesis and proliferation. Cbk1p, a member of
this family in Saccharomyces cerevisiae, has previously been shown to be required for normal morphogenesis in vegetatively growing cells and in haploid cells responding to mating pheromone. A
mutant of PAG1, a novel gene in S.
cerevisiae, displayed defects similar to those of
cbk1 mutants. pag1 and
cbk1 mutants share a common set of suppressors,
including the disruption of SSD1, a gene encoding an RNA
binding protein, and the overexpression of Sim1p, an extracellular
protein. These genetic results suggest that PAG1 and
CBK1 act in the same pathway. Furthermore, we found that
Pag1p and Cbk1p localize to the same polarized peripheral sites and
that they coimmunoprecipitate with each other. Pag1p is a conserved
protein. The homologs of Pag1p in other organisms are likely to form
complexes with the Cbk1p-related kinases and function with those
kinases in the same biological processes.
Cell Biology, Yale University School of Medicine, New
Haven, Connecticut 06520
Present address: Department of Molecular Biology,
The Scripps Research Institute, 10550 North Torrey Pines Rd., La Jolla, CA 92037.
§
Corresponding author. E-mail address:
peter.novick{at}yale.edu.
This article has been cited by other articles:
|
|
 |
|
  Y. Song, S. A. Cheon, K. E. Lee, S.-Y. Lee, B.-K. Lee, D.-B. Oh, H. A. Kang, and J.-Y. Kim Role of the RAM Network in Cell Polarity and Hyphal Morphogenesis in Candida albicans Mol. Biol. Cell, December 1, 2008; 19(12): 5456 - 5477. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Kurischko, V. K. Kuravi, N. Wannissorn, P. A. Nazarov, M. Husain, C. Zhang, K. M. Shokat, J. M. McCaffery, and F. C. Luca The Yeast LATS/Ndr Kinase Cbk1 Regulates Growth via Golgi-dependent Glycosylation and Secretion Mol. Biol. Cell, December 1, 2008; 19(12): 5559 - 5578. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Qiu, J. Eifert, L. Wacheul, M. Thiry, A. C. Berger, J. Jakovljevic, J. L. Woolford Jr., A. H. Corbett, D. L. J. Lafontaine, R. M. Terns, et al. Identification of Genes That Function in the Biogenesis and Localization of Small Nucleolar RNAs in Saccharomyces cerevisiae Mol. Cell. Biol., June 1, 2008; 28(11): 3686 - 3699. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Larance, G. Ramm, and D. E. James The GLUT4 Code Mol. Endocrinol., February 1, 2008; 22(2): 226 - 233. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Li, S. Agarwal, and G. S. Roeder SSP2 and OSW1, Two Sporulation-Specific Genes Involved in Spore Morphogenesis in Saccharomyces cerevisiae Genetics, January 1, 2007; 175(1): 143 - 154. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. M. Jansen, M. F. Barry, C. K. Yoo, and E. L. Weiss Phosphoregulation of Cbk1 is critical for RAM network control of transcription and morphogenesis J. Cell Biol., December 4, 2006; 175(5): 755 - 766. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Seiler, N. Vogt, C. Ziv, R. Gorovits, and O. Yarden The STE20/Germinal Center Kinase POD6 Interacts with the NDR Kinase COT1 and Is Involved in Polar Tip Extension in Neurospora crassa Mol. Biol. Cell, September 1, 2006; 17(9): 4080 - 4092. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Kurischko, G. Weiss, M. Ottey, and F. C. Luca A Role for the Saccharomyces cerevisiae Regulation of Ace2 and Polarized Morphogenesis Signaling Network in Cell Integrity Genetics, October 1, 2005; 171(2): 443 - 455. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. He, K. Emoto, X. Fang, N. Ren, X. Tian, Y.-N. Jan, and P. N. Adler Drosophila Mob Family Proteins Interact with the Related Tricornered (Trc) and Warts (Wts) Kinases Mol. Biol. Cell, September 1, 2005; 16(9): 4139 - 4152. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. P. Voth, A. E. Olsen, M. Sbia, K. H. Freedman, and D. J. Stillman ACE2, CBK1, and BUD4 in Budding and Cell Separation Eukaryot. Cell, June 1, 2005; 4(6): 1018 - 1028. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. He, X. Fang, K. Emoto, Y.-N. Jan, and P. N. Adler The Tricornered Ser/Thr Protein Kinase Is Regulated by Phosphorylation and Interacts with Furry during Drosophila Wing Hair Development Mol. Biol. Cell, February 1, 2005; 16(2): 689 - 700. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. J. Bichsel, R. Tamaskovic, M. R. Stegert, and B. A. Hemmings Mechanism of Activation of NDR (Nuclear Dbf2-related) Protein Kinase by the hMOB1 Protein J. Biol. Chem., August 20, 2004; 279(34): 35228 - 35235. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. R. Stegert, R. Tamaskovic, S. J. Bichsel, A. Hergovich, and B. A. Hemmings Regulation of NDR2 Protein Kinase by Multi-site Phosphorylation and the S100B Calcium-binding Protein J. Biol. Chem., May 28, 2004; 279(22): 23806 - 23812. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Kaeberlein, A. A. Andalis, G. B. Liszt, G. R. Fink, and L. Guarente Saccharomyces cerevisiae SSD1-V Confers Longevity by a Sir2p-Independent Mechanism Genetics, April 1, 2004; 166(4): 1661 - 1672. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Schneper, A. Krauss, R. Miyamoto, S. Fang, and J. R. Broach The Ras/Protein Kinase A Pathway Acts in Parallel with the Mob2/Cbk1 Pathway To Effect Cell Cycle Progression and Proper Bud Site Selection Eukaryot. Cell, February 1, 2004; 3(1): 108 - 120. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Nelson, C. Kurischko, J. Horecka, M. Mody, P. Nair, L. Pratt, A. Zougman, L. D.B. McBroom, T. R. Hughes, C. Boone, et al. RAM: A Conserved Signaling Network That Regulates Ace2p Transcriptional Activity and Polarized Morphogenesis Mol. Biol. Cell, September 1, 2003; 14(9): 3782 - 3803. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. M. Coll, Y. Trillo, A. Ametzazurra, and P. Perez Gef1p, a New Guanine Nucleotide Exchange Factor for Cdc42p, Regulates Polarity in Schizosaccharomyces pombe Mol. Biol. Cell, January 1, 2003; 14(1): 313 - 323. [Abstract] [Full Text]
|
|
|
|
|
|
P. Jorgensen, B. Nelson, M. D. Robinson, Y. Chen, B. Andrews, M. Tyers, and C. Boone High-Resolution Genetic Mapping With Ordered Arrays of Saccharomyces cerevisiae Deletion Mutants Genetics, November 1, 2002; 162(3): 1091 - 1099. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X. Fei, B. He, and P. N. Adler The growth of Drosophila bristles and laterals is not restricted to the tip or base J. Cell Sci., January 10, 2002; 115(19): 3797 - 3806. [Abstract] [Full Text] [PDF]
|
|
