![[Feedback]](/icons/banner/feedbackACT.gif){kind=icon}
![[For Subscribers]](/icons/banner/subscriberACT.gif){kind=icon}
![[Archive]](/icons/banner/archiveACT.gif){kind=icon}
![[Search]](/icons/banner/searchACT.gif){kind=icon}
![[Contents]](/icons/banner/tocACT.gif){kind=icon}
|
|
|
|
|
||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Vol. 13, Issue 6, 2031-2044, June 2002
-converting Enzyme at Threonine 735: A Potential
Role in Regulated Shedding
Instituto de Microbiología Bioquímica and Centro de
Investigación del Cáncer, Consejo Superior de
Investigaciones Científicas-Universidad de Salamanca,
37007-Salamanca, Spain
The ectodomain of certain transmembrane proteins can be released by
the action of cell surface proteases, termed secretases. Here we
have investigated how mitogen-activated protein kinases (MAPKs) control
the shedding of membrane proteins. We show that extracellular
signal-regulated kinase (Erk) acts as an intermediate in protein kinase
C-regulated TrkA cleavage. We report that the cytosolic tail of the
tumor necrosis factor 
-converting enzyme (TACE) is phosphorylated by
Erk at threonine 735. In addition, we show that Erk and TACE associate.
This association is favored by Erk activation and by the presence of
threonine 735. In contrast to the Erk route, the p38 MAPK was able to
stimulate TrkA cleavage in cells devoid of TACE activity, indicating
that other proteases are also involved in TrkA shedding. These results
demonstrate that secretases are able to discriminate between the
different stimuli that trigger membrane protein ectodomain cleavage and indicate that phosphorylation by MAPKs may regulate the proteolytic function of membrane secretases.
This article has been cited by other articles:
|
|
 |
|
  K. D. Rodland, N. Bollinger, D. Ippolito, L. K. Opresko, R. J. Coffey, R. Zangar, and H. S. Wiley Multiple Mechanisms Are Responsible for Transactivation of the Epidermal Growth Factor Receptor in Mammary Epithelial Cells J. Biol. Chem., November 14, 2008; 283(46): 31477 - 31487. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Andric and M. Ascoli The Luteinizing Hormone Receptor-Activated Extracellularly Regulated Kinase-1/2 Cascade Stimulates Epiregulin Release from Granulosa Cells Endocrinology, November 1, 2008; 149(11): 5549 - 5556. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Diaz-Rodriguez, R. Sotillo, J.-M. Schvartzman, and R. Benezra Hec1 overexpression hyperactivates the mitotic checkpoint and induces tumor formation in vivo PNAS, October 28, 2008; 105(43): 16719 - 16724. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. E. Wang, B. Xiang, M. Guix, M. G. Olivares, J. Parker, C. H. Chung, A. Pandiella, and C. L. Arteaga Transforming Growth Factor {beta} Engages TACE and ErbB3 To Activate Phosphatidylinositol-3 Kinase/Akt in ErbB2-Overexpressing Breast Cancer and Desensitizes Cells to Trastuzumab Mol. Cell. Biol., September 15, 2008; 28(18): 5605 - 5620. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. C. Montero, R. Rodriguez-Barrueco, A. Ocana, E. Diaz-Rodriguez, A. Esparis-Ogando, and A. Pandiella Neuregulins and Cancer Clin. Cancer Res., June 1, 2008; 14(11): 3237 - 3241. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Paland, L. Bohme, R. K. Gurumurthy, A. Maurer, A. J. Szczepek, and T. Rudel Reduced Display of Tumor Necrosis Factor Receptor I at the Host Cell Surface Supports Infection with Chlamydia trachomatis J. Biol. Chem., March 7, 2008; 283(10): 6438 - 6448. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Rousseau, M. Papoutsopoulou, A. Symons, D. Cook, J. M. Lucocq, A. R. Prescott, A. O'Garra, S. C. Ley, and P. Cohen TPL2-mediated activation of ERK1 and ERK2 regulates the processing of pre-TNF{alpha} in LPS-stimulated macrophages J. Cell Sci., January 15, 2008; 121(2): 149 - 154. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z. Zhang, B. D. Humphreys, and J. V. Bonventre Shedding of the Urinary Biomarker Kidney Injury Molecule-1 (KIM-1) Is Regulated by MAP Kinases and Juxtamembrane Region J. Am. Soc. Nephrol., October 1, 2007; 18(10): 2704 - 2714. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Keates, X. Han, C. P. Kelly, and A. C. Keates Macrophage-Inflammatory Protein-3{alpha} Mediates Epidermal Growth Factor Receptor Transactivation and ERK1/2 MAPK Signaling in Caco-2 Colonic Epithelial Cells via Metalloproteinase-Dependent Release of Amphiregulin J. Immunol., June 15, 2007; 178(12): 8013 - 8021. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Alfa Cisse, C. Sunyach, B. E. Slack, A. Fisher, B. Vincent, and F. Checler M1 and M3 Muscarinic Receptors Control Physiological Processing of Cellular Prion by Modulating ADAM17 Phosphorylation and Activity J. Neurosci., April 11, 2007; 27(15): 4083 - 4092. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Urra, C. A. Escudero, P. Ramos, F. Lisbona, E. Allende, P. Covarrubias, J. I. Parraguez, N. Zampieri, M. V. Chao, W. Annaert, et al. TrkA Receptor Activation by Nerve Growth Factor Induces Shedding of the p75 Neurotrophin Receptor Followed by Endosomal {gamma}-Secretase-mediated Release of the p75 Intracellular Domain J. Biol. Chem., March 9, 2007; 282(10): 7606 - 7615. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Horiuchi, S. Le Gall, M. Schulte, T. Yamaguchi, K. Reiss, G. Murphy, Y. Toyama, D. Hartmann, P. Saftig, and C. P. Blobel Substrate Selectivity of Epidermal Growth Factor-Receptor Ligand Sheddases and their Regulation by Phorbol Esters and Calcium Influx Mol. Biol. Cell, January 1, 2007; 18(1): 176 - 188. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Ohtsu, P. J. Dempsey, G. D. Frank, E. Brailoiu, S. Higuchi, H. Suzuki, H. Nakashima, K. Eguchi, and S. Eguchi ADAM17 Mediates Epidermal Growth Factor Receptor Transactivation and Vascular Smooth Muscle Cell Hypertrophy Induced by Angiotensin II Arterioscler. Thromb. Vasc. Biol., September 1, 2006; 26(9): e133 - e137. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Wang and H. S. Sul Ectodomain Shedding of Preadipocyte Factor 1 (Pref-1) by Tumor Necrosis Factor Alpha Converting Enzyme (TACE) and Inhibition of Adipocyte Differentiation. Mol. Cell. Biol., July 1, 2006; 26(14): 5421 - 5435. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Ohtsu, P. J. Dempsey, and S. Eguchi ADAMs as mediators of EGF receptor transactivation by G protein-coupled receptors Am J Physiol Cell Physiol, July 1, 2006; 291(1): C1 - C10. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Q. Zhang, S. M. Thomas, V. W. Y. Lui, S. Xi, J. M. Siegfried, H. Fan, T. E. Smithgall, G. B. Mills, and J. R. Grandis Phosphorylation of TNF-{alpha} converting enzyme by gastrin-releasing peptide induces amphiregulin release and EGF receptor activation PNAS, May 2, 2006; 103(18): 6901 - 6906. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Maretzky, M. Schulte, A. Ludwig, S. Rose-John, C. Blobel, D. Hartmann, P. Altevogt, P. Saftig, and K. Reiss L1 Is Sequentially Processed by Two Differently Activated Metalloproteases and Presenilin/{gamma}-Secretase and Regulates Neural Cell Adhesion, Cell Migration, and Neurite Outgrowth Mol. Cell. Biol., October 15, 2005; 25(20): 9040 - 9053. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. D. Sternlicht, S. W. Sunnarborg, H. Kouros-Mehr, Y. Yu, D. C. Lee, and Z. Werb Mammary ductal morphogenesis requires paracrine activation of stromal EGFR via ADAM17-dependent shedding of epithelial amphiregulin Development, September 1, 2005; 132(17): 3923 - 3933. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Li, R. F. Schwabe, T. DeVries-Seimon, P. M. Yao, M.-C. Gerbod-Giannone, A. R. Tall, R. J. Davis, R. Flavell, D. A. Brenner, and I. Tabas Free Cholesterol-loaded Macrophages Are an Abundant Source of Tumor Necrosis Factor-{alpha} and Interleukin-6: MODEL OF NF-{kappa}B- AND MAP KINASE-DEPENDENT INFLAMMATION IN ADVANCED ATHEROSCLEROSIS J. Biol. Chem., June 10, 2005; 280(23): 21763 - 21772. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. M. Soond, B. Everson, D. W. H. Riches, and G. Murphy ERK-mediated phosphorylation of Thr735 in TNF{alpha}-converting enzyme and its potential role in TACE protein trafficking J. Cell Sci., June 1, 2005; 118(11): 2371 - 2380. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Li, D. Georgakopoulos, G. Lu, L. Hester, D. A. Kass, J. Hasday, and Y. Wang p38 MAP Kinase Mediates Inflammatory Cytokine Induction in Cardiomyocytes and Extracellular Matrix Remodeling in Heart Circulation, May 17, 2005; 111(19): 2494 - 2502. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. P. Sanderson, S. N. Erickson, P. J. Gough, K. J. Garton, P. T. Wille, E. W. Raines, A. J. Dunbar, and P. J. Dempsey ADAM10 Mediates Ectodomain Shedding of the Betacellulin Precursor Activated by p-Aminophenylmercuric Acetate and Extracellular Calcium Influx J. Biol. Chem., January 21, 2005; 280(3): 1826 - 1837. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Sundberg, C. K. Thodeti, M. Kveiborg, C. Larsson, P. Parker, R. Albrechtsen, and U. M. Wewer Regulation of ADAM12 Cell-surface Expression by Protein Kinase C {epsilon} J. Biol. Chem., December 3, 2004; 279(49): 51601 - 51611. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. J. Levine Mechanisms of Soluble Cytokine Receptor Generation J. Immunol., November 1, 2004; 173(9): 5343 - 5348. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R.-R. Ji and G. Strichartz Cell Signaling and the Genesis of Neuropathic Pain Sci. Signal., September 28, 2004; 2004(252): re14 - re14. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Thathiah, M. Brayman, N. Dharmaraj, J. J. Julian, E. L. Lagow, and D. D. Carson Tumor Necrosis Factor {alpha} Stimulates MUC1 Synthesis and Ectodomain Release in a Human Uterine Epithelial Cell Line Endocrinology, September 1, 2004; 145(9): 4192 - 4203. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. L. Tsakadze, U. Sen, Z. Zhao, S. D. Sithu, W. R. English, and S. E. D'Souza Signals mediating cleavage of intercellular adhesion molecule-1 Am J Physiol Cell Physiol, July 1, 2004; 287(1): C55 - C63. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Li and H. Fan Loss of Ectodomain Shedding Due to Mutations in the Metalloprotease and Cysteine-rich/Disintegrin Domains of the Tumor Necrosis Factor-{alpha} Converting Enzyme (TACE) J. Biol. Chem., June 25, 2004; 279(26): 27365 - 27375. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 O. Nagano, D. Murakami, D. Hartmann, B. de Strooper, P. Saftig, T. Iwatsubo, M. Nakajima, M. Shinohara, and H. Saya Cell-matrix interaction via CD44 is independently regulated by different metalloproteinases activated in response to extracellular Ca2+ influx and PKC activation J. Cell Biol., June 21, 2004; 165(6): 893 - 902. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. M. Fischer, S. Hart, A. Gschwind, N. Prenzel, and A. Ullrich Oxidative and Osmotic Stress Signaling in Tumor Cells Is Mediated by ADAM Proteases and Heparin-Binding Epidermal Growth Factor Mol. Cell. Biol., June 15, 2004; 24(12): 5172 - 5183. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W.-N. U. Chen, R. L. Woodbury, L. E. Kathmann, L. K. Opresko, R. C. Zangar, H. S. Wiley, and B. D. Thrall Induced Autocrine Signaling through the Epidermal Growth Factor Receptor Contributes to the Response of Mammary Epithelial Cells to Tumor Necrosis Factor {alpha} J. Biol. Chem., April 30, 2004; 279(18): 18488 - 18496. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. V. Maly, H. S. Wiley, and D. A. Lauffenburger Self-Organization of Polarized Cell Signaling via Autocrine Circuits: Computational Model Analysis Biophys. J., January 1, 2004; 86(1): 10 - 22. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. M. Le Gall, R. Auger, C. Dreux, and P. Mauduit Regulated Cell Surface Pro-EGF Ectodomain Shedding Is a Zinc Metalloprotease-dependent Process J. Biol. Chem., November 14, 2003; 278(46): 45255 - 45268. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Walcheck, S. R. Alexander, C. A. St. Hill, and E. Matala ADAM-17-independent shedding of L-selectin J. Leukoc. Biol., September 1, 2003; 74(3): 389 - 394. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Peiretti, P. Deprez-Beauclair, B. Bonardo, H. Aubert, I. Juhan-Vague, and G. Nalbone Identification of SAP97 as an intracellular binding partner of TACE J. Cell Sci., May 15, 2003; 116(10): 1949 - 1957. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Fan, C. W. Turck, and R. Derynck Characterization of Growth Factor-induced Serine Phosphorylation of Tumor Necrosis Factor-alpha Converting Enzyme and of an Alternatively Translated Polypeptide J. Biol. Chem., May 9, 2003; 278(20): 18617 - 18627. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X.-J. Zhao, L. Marrero, K. Song, P. Oliver, S. Y. Chin, H. Simon, J. R. Schurr, Z. Zhang, D. Thoppil, S. Lee, et al. Acute Alcohol Inhibits TNF-{alpha} Processing in Human Monocytes by Inhibiting TNF/TNF-{alpha}-Converting Enzyme Interactions in the Cell Membrane J. Immunol., March 15, 2003; 170(6): 2923 - 2931. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Pribyl, C. B. Muratov, and S. Y. Shvartsman Long-Range Signal Transmission in Autocrine Relays Biophys. J., February 1, 2003; 84(2): 883 - 896. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Thathiah, C. P. Blobel, and D. D. Carson Tumor Necrosis Factor-alpha Converting Enzyme/ADAM 17 Mediates MUC1 Shedding J. Biol. Chem., January 24, 2003; 278(5): 3386 - 3394. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. F. Seals and S. A. Courtneidge The ADAMs family of metalloproteases: multidomain proteins with multiple functions Genes & Dev., January 1, 2003; 17(1): 7 - 30. [Full Text] [PDF]
|
|
