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Vol. 15, Issue 4, 1853-1861, April 2004

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The Oxa2 Protein of Neurospora crassa Plays a Critical Role in the Biogenesis of Cytochrome Oxidase and Defines a Ubiquitous Subbranch of the Oxa1/YidC/Alb3 Protein Family

Soledad Funes ^*, Frank E. Nargang , Walter Neupert ^*, and Johannes M. Herrmann ^* 

^* Institut für Physiologische Chemie, Universität München, 81377 München, Germany; Department of Biological Sciences, University of Alberta, Edmonton, Alberta, Canada T6G 2E9

Submitted November 6, 2003; Revised January 20, 2004; Accepted January 22, 2004
Monitoring Editor: Thomas Fox

Proteins of the Oxa1/YidC/Alb3 family mediate the insertion of proteins into membranes of mitochondria, bacteria, and chloroplasts. Here we report the identification of a second gene of the Oxa1/YidC/Alb3 family in the genome of Neurospora crassa, which we have named oxa2. Its gene product, Oxa2, is located in the inner membrane of mitochondria. Deletion of the oxa2 gene caused a specific defect in the biogenesis of cytochrome oxidase and resulted in induction of the alternative oxidase (AOD), which bypasses the need for complex IV of the respiratory chain. The Oxa2 protein of N. crassa complements Cox18-deficient yeast mutants suggesting a common function for both proteins. The oxa2 sequence allowed the identification of a new subfamily of Oxa1/YidC/Alb3 proteins whose members appear to be ubiquitously present in mitochondria of fungi, plants, and animals including humans.

Online version of this article contains supplementary material. Online version is available at www.molbiolcell.org.

Corresponding author. E-mail address: hannes.herrmann{at}bio.med.uni-muenchen.de.

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