Molecular Biology of the Cell Call for Nominations: MBC Editor-in-Chief

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

Originally published as MBC in Press, 10.1091/mbc.E07-01-0006 on May 2, 2007

Vol. 18, Issue 7, 2678-2686, July 2007

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Supplemental Material
Right arrow All Versions of this Article:
E07-01-0006v1
18/7/2678    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Whitney, M. L.
Right arrow Articles by Hopper, A. K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Whitney, M. L.
Right arrow Articles by Hopper, A. K.

Rapid and Reversible Nuclear Accumulation of Cytoplasmic tRNA in Response to Nutrient AvailabilityFormula

Michael L. Whitney*,{dagger}, Rebecca L. Hurto{ddagger}, Hussam H. Shaheen{ddagger},§, and Anita K. Hopper{ddagger}

*Department of Biochemistry and Molecular Biology, Pennsylvania State University College of Medicine, Hershey, PA 17033; and {ddagger}Department of Molecular Genetics, The Ohio State University, Columbus, OH 43210

Submitted January 8, 2007; Revised April 2, 2007; Accepted April 20, 2007
Monitoring Editor: Thomas Fox

Cytoplasmic tRNAs have recently been found to accumulate in the nucleus during amino acid starvation in yeast. The mechanism and regulation by which tRNAs return to the nucleus are unclear. Here, we show accumulation of cytoplasmic tRNA in the nucleus also occurs during glucose starvation. Nuclear accumulation of tRNA in response to acute glucose or amino acid starvation is rapid, reversible, requires no new transcription, and is independent of the aminoacylation status of tRNA. Gradual depletion of nutrients also results in the accrual of tRNA in the nucleus. Distinct signal transduction pathways seem to be involved in the accumulation of cytoplasmic tRNA in the nucleus in response to amino acid versus glucose starvation. These findings suggest tRNA nucleocytoplasmic distribution may play a role in gene expression in response to nutritional stress.

This article was published online ahead of print in MBC in Press (http://www.molbiolcell.org/cgi/doi/10.1091/mbc.E07-01-0006) on May 2, 2007.

Formula The online version of this article contains supplemental material at MBC Online (http://www.molbiolcell.org).

Present addresses: {dagger}Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, H166, Hershey, PA 17033;

§ Avon Products, Inc., Suffern, NY 10901.

Address correspondence to: Anita K. Hopper (hopper.64{at}osu.edu)




This article has been cited by other articles:


Home page
 Nucleic Acids ResHome page
Y. Li, J. Luo, H. Zhou, J.-Y. Liao, L.-M. Ma, Y.-Q. Chen, and L.-H. Qu
Stress-induced tRNA-derived RNAs: a novel class of small RNAs in the primitive eukaryote Giardia lamblia
Nucleic Acids Res., November 1, 2008; 36(19): 6048 - 6055.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
I. Chernyakov, J. M. Whipple, L. Kotelawala, E. J. Grayhack, and E. M. Phizicky
Degradation of several hypomodified mature tRNA species in Saccharomyces cerevisiae is mediated by Met22 and the 5'-3' exonucleases Rat1 and Xrn1
Genes & Dev., May 15, 2008; 22(10): 1369 - 1380.
[Abstract] [Full Text] [PDF]


Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
Copyright © 2007 by The American Society for Cell Biology. Terms of copyright protection, warranties, and disclaimers.