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Vol. 19, Issue 1, 1-7, January 2008

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Essay

Chromatin Challenges during DNA Replication: A Systems Representation

Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892

Monitoring Editor: Gerard Evan

In a recent review, A. Groth and coworkers presented a comprehensive account of nucleosome disassembly in front of a DNA replication fork, assembly behind the replication fork, and the copying of epigenetic information onto the replicated chromatin. Understanding those processes however would be enhanced by a comprehensive graphical depiction analogous to a circuit diagram. Accordingly, we have constructed a molecular interaction map (MIM) that preserves in essentially complete detail the processes described by Groth et al. The MIM organizes and elucidates the information presented by Groth et al. on the complexities of chromatin replication, thereby providing a tool for system-level comprehension of the effects of genetic mutations, altered gene expression, and pharmacologic intervention.

¹ References relating to each interaction shown in Figure 2 are cited in Appendix 2 and in the annotations associated with the eMIM at http://discover.nci.nih.gov/mim.

² The annotation references include those cited by Groth et al. (2007).

Address correspondence to: Kurt W. Kohn (kohnk{at}dc37a.nci.nih.gov)