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MBC in Press, published online ahead of print September 24, 2002
Mol. Biol. Cell 10.1091/mbc.E02-02-0105

A more recent version of this article appeared on December 1, 2002
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Submitted on February 25, 2002
Revised on June 21, 2002
Accepted on August 23, 2002

HUMAN ADIPOSE TISSUE IS A SOURCE OF MULTIPOTENT STEM CELLS

Patricia A. Zuk1*, Min Zhu2, Peter Ashjian2, Daniel A. De Ugarte2, Jerry I. Huang2, Hiroshi Mizuno2, Zeni C. Alfonso2, John K. Fraser2, Prosper Benhaim2, and Marc H. Hedrick2

1 Regenerative Bioengineering and Repair Laboratory, UCLA School of Medicine, Departments of Surgery and Orthopedics, Los Angeles, CA 90095
2 Regenerative Bioengineering and Repair Laboratory, UCLA School of Medicine, Departments of Surgery and Orthopedics, Los Angeles, CA 90095

* Corresponding author. E-mail address: zukpat{at}yahoo.com.

Much of the work conducted on adult stem cells has focused on mesenchymal stem cells (MSCs) found within the bone marrow stroma. Adipose tissue, like bone marrow, is derived from the embryonic mesenchyme and contains a stroma that is easily isolated. Preliminary studies have recently identified a putative stem cell population within the adipose stromal compartment. This cell population, termed Processed Lipoaspirate (PLA) cells, can be isolated from human lipoaspirates and, like MSCs, differentiate toward the osteogenic, adipogenic, myogenic and chondrogenic lineages. To confirm if adipose tissue contains stem cells, the PLA population and multiple clonal isolates were analyzed using several molecular and biochemical approaches. PLA cells expressed multiple CD marker antigens similar to those observed on MSCs. Mesodermal lineage induction of PLA cells and clones resulted in the expression of multiple lineage-specific genes and proteins. Furthermore, biochemical analysis also confirmed lineage-specific activity. In addition to mesodermal capacity, PLA cells and clones differentiated into putative neurogenic cells, exhibiting a neuronal-like morphology and expressing several proteins consistent with the neuronal phenotype. Finally, PLA cells exhibited unique characteristics distinct from those seen in MSCs, including differences in CD marker profile and gene expression.




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[Abstract] [Full Text] [PDF]

Home page
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J. Immunol., September 1, 2007; 179(5): 2824 - 2831.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
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[Abstract] [Full Text] [PDF]

Home page
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[Abstract] [Full Text] [PDF]

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[Abstract] [Full Text] [PDF]

Home page
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[Abstract] [Full Text] [PDF]

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[Abstract] [Full Text] [PDF]

Home page
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J. M. Gimble, A. J. Katz, and B. A. Bunnell
Adipose-Derived Stem Cells for Regenerative Medicine
Circ. Res., May 11, 2007; 100(9): 1249 - 1260.
[Abstract] [Full Text] [PDF]

Home page
 Stem CellsHome page
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[Abstract] [Full Text] [PDF]

Home page
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[Abstract] [Full Text] [PDF]

Home page
 Stem CellsHome page
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Stem Cells, April 1, 2007; 25(4): 818 - 827.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Roentgenol.Home page
H. E. Rice, E. W. Hsu, H. Sheng, D. A. Evenson, A. J. Freemerman, K. M. Safford, J. M. Provenzale, D. S. Warner, and G. A. Johnson
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Am. J. Roentgenol., April 1, 2007; 188(4): 1101 - 1108.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
C.-H. Cho, Y. Jun Koh, J. Han, H.-K. Sung, H. Jong Lee, T. Morisada, R. A. Schwendener, R. A. Brekken, G. Kang, Y. Oike, et al.
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Circ. Res., March 2, 2007; 100(4): e47 - e57.
[Abstract] [Full Text] [PDF]

Home page
 Stem CellsHome page
T. M. Liu, M. Martina, D. W. Hutmacher, J. H. P. Hui, E. H. Lee, and B. Lim
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[Abstract] [Full Text] [PDF]

Home page
 Stem CellsHome page
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[Abstract] [Full Text] [PDF]

Home page
 Stem CellsHome page
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Stem Cells, March 1, 2007; 25(3): 790 - 797.
[Abstract] [Full Text] [PDF]

Home page
 J. Gerontol. A Biol. Sci. Med. Sci.Home page
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J. Gerontol. A Biol. Sci. Med. Sci., January 1, 2007; 62(1): 3 - 8.
[Abstract] [Full Text] [PDF]

Home page
 Hum Reprod UpdateHome page
C.E. Gargett
Uterine stem cells: What is the evidence?
Hum. Reprod. Update, January 1, 2007; 13(1): 87 - 101.
[Abstract] [Full Text] [PDF]

Home page
 Stem CellsHome page
Q. He, C. Wan, and G. Li
Concise Review: Multipotent Mesenchymal Stromal Cells in Blood
Stem Cells, January 1, 2007; 25(1): 69 - 77.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
M. E. Trujillo and P. E. Scherer
Adipose Tissue-Derived Factors: Impact on Health and Disease
Endocr. Rev., December 1, 2006; 27(7): 762 - 778.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. GenomicsHome page
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Transcriptome of the subcutaneous adipose tissue in response to oral supplementation of type 2 Leprdb obese diabetic mice with niacin-bound chromium
Physiol Genomics, November 21, 2006; 27(3): 370 - 379.
[Abstract] [Full Text] [PDF]

Home page
 Eur. J. Cardiothorac. Surg.Home page
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Eur. J. Cardiothorac. Surg., November 1, 2006; 30(5): 770 - 781.
[Abstract] [Full Text] [PDF]

Home page
 J. Dent. Res.Home page
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Craniofacial tissue engineering by stem cells.
J. Dent. Res., November 1, 2006; 85(11): 966 - 979.
[Abstract] [Full Text] [PDF]

Home page
 Stem CellsHome page
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[Abstract] [Full Text] [PDF]

Home page
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Home page
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[Abstract] [Full Text] [PDF]

Home page
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[Abstract] [Full Text] [PDF]

Home page
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[Abstract] [Full Text] [PDF]

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