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A more recent version of this article appeared on October 1, 2002
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Submitted on May 2, 2002
Revised on July 3, 2002
Accepted on July 10, 2002
1 Biotechnology Research Institute, National Research Council of Canada, 6100 Royalmount, Montreal, PQ, Canada H4P 2R2
2 Institute for Marine Bioscience, National Research Council of Canada, Halifax, NS, Canada B3H 3Z1 (present address: Department of Biochemistry and Molecular Biology, University of Calgary, Calgary, AB Canada T2N 4N1)
3 Institute for Marine Bioscience, National Research Council of Canada, Halifax, NS, Canada B3H 3Z1
4 Biotechnology Research Institute, National Research Council of Canada, 6100 Royalmount, Montreal, PQ, Canada H4P 2R2(present address: Department of Biochemistry, McGill University, Montreal, PQ Canada H3G 1Y6)
* Corresponding author. E-mail address: andre.nantel{at}bri.nrc.ca.
The ability of the pathogenic fungus Candida albicans to switch from a yeast to a hyphal morphology in response to external signals is implicated in its pathogenicity. We used glass DNA microarrays to investigate the transcription profiles of 6333 predicted ORFs in cells undergoing this transition and their responses to changes in temperature and culture medium. We have identified several genes whose transcriptional profiles are similar to those of known virulence factors that are modulated by the switch to hyphal growth caused by addition of serum and a 37°C growth temperature. Time course analysis of this transition identified transcripts that are induced prior to germ tube initiation and shut off later in the developmental process. A strain deleted for the Efg1p and Cph1p transcription factors is defective in hyphae formation, and its response to serum and increased temperature is almost identical to the response of a wild type strain grown at 37°C in the absence of serum. Thus Efg1p and Cph1p are needed for the activation of the transcriptional program that is induced by the presence of serum.
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