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A more recent version of this article appeared on December 1, 2002
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Submitted on May 15, 2002
Revised on September 4, 2002
Accepted on September 13, 2002
1 Membrane Biology Laboratory, Institute of Molecular and Cell Biology, 30 Medical Drive, Singapore 117609, Singapore
* Corresponding author. E-mail address: mcbhwj{at}imcb.nus.edu.sg.
We present here evidence to suggest the existence of a regulatory pathway for the Golgi apparatus to modulate the spatial positioning of otherwise distantly located lysosomes. Rab34, a new member of the Rab GTPase family, is primarily associated with the Golgi apparatus. Expression of wild-type or GTP- but not GDP-restricted version of Rab34 causes spatial redistribution of lysosomes from the periphery to the peri-Golgi region. The regulation of lysosomal positioning by Rab34 depends on its association with the membrane mediated by prenylation and its direct interaction with RILP. This biological activity mediated by Rab34- RILP interaction is dependent on Lys82 in the switch I region. Our results have uncovered a novel mechanism for the Golgi apparatus to regulate the spatial distribution of another organelle.
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