Molecular Biology of the Cell Call for Nominations: MBC Editor-in-Chief

Home Help [Feedback] [For Subscribers] [Archive] [Search] --
QUICK SEARCH:   [advanced]


     

MBC in Press, published online ahead of print October 16, 2002
Mol. Biol. Cell 10.1091/mbc.E02-05-0297

A more recent version of this article appeared on January 1, 2003
This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
E02-05-0297v1
14/1/241    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Botella, J. A.
Right arrow Articles by Schneuwly, S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Botella, J. A.
Right arrow Articles by Schneuwly, S.

Submitted on May 24, 2002
Revised on September 4, 2002
Accepted on September 17, 2002

Deregulation of the Egfr/Ras signaling pathway induces age-related brain degeneration in the Drosophila mutant vap

José A. Botella1*, Doris Kretzschmar1, Claudia Kiermayer1, Pascale Feldmann2, David A. Hughes3, and Stephan Schneuwly1

1 Lehrstuhl für Entwicklungsbiologie, Universität Regensburg, 93040 Regensburg, Germany
2 CRC Centre for Cell and Molecular Biology, Institute of Cancer Research, Fulham Road, London SW3 6JB, UK
3 CRC Centre for Cell and Molecular Biology, Institute of Cancer Research, Fulham Road, London SW3 6JB, UK (present address: Biomolecular Sciences, UMIST, Manchester M60 1QD, UK)

* Corresponding author. E-mail address: jose.botella-munozbiologie.uni-regensburg.de.

Ras signaling has been shown to play an important role in promoting cell survival in many different tissues. Here we show that upregulation of Ras activity in adult Drosophila neurons induces neuronal cell death as evident from the phenotype of vacuolar peduncle (vap) mutants defective in the Drosophila RasGAP gene, which encodes a Ras GTPase-activating protein. These mutants show age-related brain degeneration that is dependent upon activation of the EGF receptor signaling pathway in adult neurons leading to autophagic cell death (cell death type 2). These results provide the first evidence for a requirement of Egf receptor activity in differentiated adult Drosophila neurons and show that a delicate balance of Ras activity is essential for the survival of adult neurons.




This article has been cited by other articles:


Home page
 J. Neurosci.Home page
B. A. Gavin, M. J. Dolph, N. R. Deleault, J. C. Geoghegan, V. Khurana, M. B. Feany, P. J. Dolph, and S. Supattapone
Accelerated Accumulation of Misfolded Prion Protein and Spongiform Degeneration in a Drosophila Model of Gerstmann-Straussler-Scheinker Syndrome
J. Neurosci., November 29, 2006; 26(48): 12408 - 12414.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Interv.Home page
A. M. Celotto and M. J. Palladino
Drosophila: A "Model" Model System To Study Neurodegeneration
Mol. Interv., October 1, 2005; 5(5): 292 - 303.
[Abstract] [Full Text] [PDF]


Home Help [Feedback] [For Subscribers] [Archive] [Search] --
Copyright © 2002 by The American Society for Cell Biology. Terms of copyright protection, warranties, and disclaimers.