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MBC in Press, published online ahead of print September 5, 2003
Mol. Biol. Cell 10.1091/mbc.E03-06-0395

A more recent version of this article appeared on December 1, 2003
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Submitted on June 12, 2003
Revised on July 18, 2003
Accepted on August 8, 2003

Diffusion-based Transport of Nascent Ribosomes in the Nucleus

Joan C. Ritland Politz1*, Richard A. Tuft2, and Thoru Pederson3

1 Department of Biochemistry and Molecular Pharmacology, Department of Physiology, and Program in Cell Dynamics, University of Massachusetts Medical School, Worcester, Massachusetts 01605
2 Department of Physiology, and Program in Cell Dynamics, University of Massachusetts Medical School, Worcester, Massachusetts 01605, and Program in Cell Dynamics, University of Massachusetts Medical School, Worcester, Massachusetts 01605
3 Department of Biochemistry and Molecular Pharmacology, Program in Cell Dynamics, University of Massachusetts Medical School, Worcester, Massachusetts 01605

* Corresponding author. E-mail address: joan.politz{at}umassmed.edu.

Although the complex process of ribosome assembly in the nucleolus is beginning to be understood, little is known about how the ribosomal subunits move from the nucleolus to the nuclear membrane for transport to the cytoplasm. We show here that large ribosomal subunits move out from the nucleolus and into the nucleoplasm in all directions, with no evidence of concentrated movement along directed paths. Mobility was slowed compared with that expected in aqueous solution in a manner consistent with anomalous diffusion. Once nucleoplasmic, the subunits moved in the same random manner, and also sometimes visited another nucleolus before leaving the nucleus.




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