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A more recent version of this article appeared on February 1, 2004
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Submitted on September 19, 2003
Revised on October 8, 2003
Accepted on October 9, 2003
1 Department of Cell Biology, University of Alberta, Edmonton, Alberta T6G 2H7, Canada
2 Department of Cell Biology, University of Alberta, Edmonton, Alberta T6G 2H7, Canada; Instituto de Investigaciones en Biologiá Experimental, University of Guanajuato, Guanajuato, Mexico
3 The Institute for Systems Biology, Seattle, Washington 98103
4 Department of Cell Biology, University of
Alberta, Medical Sciences Building 5-14, Edmonton, Alberta T6G 2H7,
Canada
* Corresponding author. E-mail address: rick.rachubinski{at}ualberta.ca.
The peroxin Pex23p of the yeast Yarrowia lipolytica exhibits high sequence similarity to the hypothetical proteins Ylr324p, Ygr004p and Ybr168p encoded by the S. cerevisiae genome. Ylr324p, Ygr004p and Ybr168p are integral to the peroxisomal membrane and act to control peroxisome number and size. Synthesis of Ylr324p and Ybr168p, but not of Ygr004p, is induced during incubation of cells in oleic acid-containing medium, the metabolism of which requires intact peroxisomes. Cells deleted for YLR324w exhibit increased numbers of peroxisomes, while cells deleted for YGR004w or YBR168w exhibit enlarged peroxisomes. Ylr324p and Ybr168p cannot functionally substitute for one another or for Ygr004p, while Ygr004p shows partial functional redundancy with Ylr324p and Ybr168p. Ylr324p, Ygr004p and Ybr168p interact within themselves and with Pex28p and Pex29p, which have been shown also to regulate peroxisome size and number. Systematic deletion of genes demonstrated that PEX28 and PEX29 function upstream of YLR324w, YGR004w and YBR168w in the regulation of peroxisome proliferation. Our data suggest a role for Ylr324p, Ygr004p and Ybr168p - now designated Pex30p, Pex31p and Pex32p, respectively - together with Pex28p and Pex29p in controlling peroxisome size and proliferation in S. cerevisiae.
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