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A more recent version of this article appeared on April 1, 2004
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Submitted on November 6, 2003
Revised on January 20, 2004
Accepted on January 22, 2004
1 Institut für Physiologische Chemie, Universität München, Butenandtstrasse 5, 81377 München, Germany
2 Department of Biological Sciences, University of Alberta, Edmonton, Alberta, Canada T6G 2E9
3 Institut für Physiologische Chemie, Universität München, Butenandtstrasse 5, 81377 München, Germany, Department of Biological Sciences, University of Alberta, Edmonton, Alberta, Canada T6G 2E9
* Corresponding author. E-mail address: hannes.herrmann{at}bio.med.uni-muenchen.de.
Proteins of the OxaI/YidC/Alb3 family mediate the insertion of proteins into membranes of mitochondria, bacteria and chloroplasts. Here we report the identification of a second gene of the OxaI/YidC/Alb3 family in the genome of Neurospora crassa which we have named oxa2. Its gene product, OxaII, is located in the inner membrane of mitochondria. Deletion of the oxa2 gene caused a specific defect in the biogenesis of cytochrome oxidase and resulted in induction of the alternative oxidase (AOD) which bypasses the need for complex IV of the respiratory chain. The OxaII protein of N. crassa complements Cox18-deficient yeast mutants suggesting a common function for both proteins. The oxa2 sequence allowed the identification of a new subfamily of OxaI/YidC/Alb3 proteins whose members appear to be ubiquitously present in mitochondria of fungi, plants and animals including humans.
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