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MBC in Press, published online ahead of print July 7, 2004
Mol. Biol. Cell 10.1091/mbc.E04-01-0027

A more recent version of this article appeared on September 1, 2004
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Submitted on January 14, 2004
Revised on June 10, 2004
Accepted on June 29, 2004

Targeted Disruption of the Protein Kinase SGK3/CISK Impairs Postnatal Hair Follicle Development

James A. McCormick*, Yuxi Feng{dagger}, Kevin Dawson*, Martin J. Behne{ddagger}, Benjamin Yu{ddagger}, Jian Wang*, Amanda W. Wyatt{dagger}, Guido Henke{dagger}, Florian Grahammer{dagger}, Theodora M. Mauro{ddagger}, Florian Lang{dagger}, and David Pearce*{sect}

*Departments of Medicine, and Molecular and Cellular Pharmacology, University of California, San Francisco, CA 94143; {dagger}Department of Physiology, University of Tubingen, Tubingen, Germany; and {ddagger}Department of Dermatology, University of California, San Francisco, CA 94143

Monitoring Editor: Richard Assoian

Members of the serum- and glucocorticoid-regulated kinase family are important mediators of growth factor and hormone signaling that, like their close relatives in the Akt family, are regulated by lipid products of phosphatidylinositol-3-kinase. SGK3 has been implicated in the control of cell survival and regulation of ion channel activity in cultured cells. To begin to dissect the in vivo functions of SGK3, we generated and characterized Sgk3 null mice. These mice are viable and fertile, and in contrast to mice lacking SGK1 or Akt2 respectively, display normal sodium handling and glucose tolerance. However, although normal at birth, by postpartum day 4 they have begun to display an unexpected defect in hair follicle morphogenesis. The abnormality in hair follicle development is preceded by a defect in proliferation and nuclear accumulation of {beta}-catenin in hair bulb keratinocytes. Furthermore, in cultured keratinocytes, heterologous expression of SGK3 potently modulates activation of {beta}-catenin/Lef-1-mediated gene transcription. These data establish a role for SGK3 in normal postnatal hair follicle development, possibly involving effects on {beta}-catenin/Lef-1-mediated gene transcription.

{sect}Corresponding author. E-mail: pearced{at}medicine.ucsf.edu




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