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A more recent version of this article appeared on February 1, 2005
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Submitted on July 27, 2004
Revised on November 22, 2004
Accepted on November 28, 2004
*Wellcome Trust Centre for Cell Biology, Institute of Cell Biology, School of Biological Sciences, The University of Edinburgh, Edinburgh EH9 3JR, United Kingdom; Department of Neurobiology and Behavior, The State University of New York at Stony Brook, Stony Brook, NY 11794
Monitoring Editor: Lawrence Goldstein
EB1 is a conserved microtubule plus end tracking protein considered to play crucial roles in microtubule organization and the interaction of microtubules with the cell cortex. Despite intense studies carried out in yeasts and cultured cells, the role of EB1 in multicellular systems remains to be elucidated. Here we describe the first genetic study of EB1 in developing animals. We show that one of the multiple Drosophila EB1 homologues, DmEB1, is ubiquitously expressed and has essential functions during development. Hypomorphic DmEB1 mutants show neuromuscular defects, including flightlessness and uncoordinated movement, without any general cell division defects. These defects can be partly explained by the malfunction of the chordotonal mechanosensory organs. In fact, electrophysiological measurements indicated that the auditory chordotonal organs show a reduced response to sound stimuli. The internal organization of the chordotonal organs is also affected in the mutant. Consistently, DmEB1 is enriched in those regions important for the structure and function of the organs. Therefore, DmEB1 plays a crucial role in the functional and structural integrity of the chordotonal mechanosensory organs in Drosophila.
Department of Biological Sciences, Stanford University, Stanford, CA 94305; Medical School, The University of Edinburgh, Edinburgh EH8 9AG, United Kingdom.
||Corresponding author.
E-mail: h.ohkura{at}ed.ac.uk
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