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MBC in Press, published online ahead of print December 1, 2004
Mol. Biol. Cell 10.1091/mbc.E04-10-0876

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Submitted on October 7, 2004
Revised on November 9, 2004
Accepted on November 16, 2004

Dynamics of Relative Chromosome Position during the Cell Cycle

Jeroen Essers,* Wiggert A. van Cappellen,{dagger} Arjan F. Theil,* Ellen van Drunen,* Nicolaas G. J. Jaspers,* Jan H. J. Hoeijmakers,* Claire Wyman,*{ddagger} Wim Vermeulen,* and Roland Kanaar*{ddagger}{sect}

*Department of Cell Biology & Genetics, {dagger}Department of Reproduction & Development, and {ddagger}Department of Radiation Oncology, Erasmus Medical Center, 3000 DR Rotterdam, The Netherlands

Monitoring Editor: Kerry Bloom

The position of chromosomal neighborhoods in living cells was followed using three different methods for marking chromosomal domains occupying arbitrary locations in the nucleus; photo-bleaching of GFP-labeled histone H2B, local UV-marked DNA and photo-bleaching of fluorescently labeled DNA. All methods revealed that global chromosomal organization can be reestablished through one cell division from mother to daughters. By simultaneously monitoring cell cycle stage in the cells in which relative chromosomal domain positions were tracked, we observed that chromosomal neighborhood organization is apparently lost in the early G1 phase of the cell cycle. However, the daughter cells eventually regain the general chromosomal organization pattern of their mothers suggesting an active mechanism could be at play to reestablish chromosomal neighborhoods.

{sect}Corresponding author. E-mail: r.kanaar{at}erasmusmc.nl




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