Molecular Biology of the Cell Sign up for new MBC in Press e-TOCs!

Home Help [Feedback] [For Subscribers] [Archive] [Search] --
QUICK SEARCH:   [advanced]


     

MBC in Press, published online ahead of print December 7, 2005
Mol. Biol. Cell 10.1091/mbc.E05-06-0501

A more recent version of this article appeared on February 1, 2006
This Article
Right arrow Full Text (PDF)
Right arrow Supplemental Material
Right arrow All Versions of this Article:
E05-06-0501v1
17/2/1018    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Enjalbert, B.
Right arrow Articles by Quinn, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Enjalbert, B.
Right arrow Articles by Quinn, J.

Submitted on June 7, 2005
Revised on November 2, 2005
Accepted on November 30, 2005

Role of the Hog1 Stress-activated Protein Kinase in the Global Transcriptional Response to Stress in the Fungal Pathogen Candida albicans

Brice Enjalbert,*{dagger} Deborah A. Smith,{dagger}{ddagger} Michael J. Cornell,{sect} Intikhab Alam,{sect} Susan Nicholls,*|| Alistair J.P. Brown,* and Janet Quinn{ddagger}

*Aberdeen Fungal Group, School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Aberdeen AB25 2ZD, United Kingdom; {ddagger}Institute of Cell and Molecular Biosciences, University of Newcastle upon Tyne, Newcastle upon Tyne NE2 4HH, United Kingdom; {sect}School of Computer Science, University of Manchester, Manchester M13 9PL, United Kingdom

Monitoring Editor: Susan Wente

The resistance of Candida albicans to many stresses is dependent upon the Stress Activated Protein Kinase (SAPK) Hog1. Hence we have explored the role of Hog1 in the regulation of transcriptional responses to stress. DNA microarrays were used to characterize the global transcriptional responses of HOG1 and hog1 cells to three stress conditions that activate the Hog1 SAPK: osmotic stress, oxidative stress and heavy metal stress. This revealed both stress-specific transcriptional responses, and a core transcriptional response to stress in C. albicans. The core transcriptional response was characterized by a subset of genes that responded in a stereotypical manner to all of the stresses analyzed. Inactivation of HOG1 significantly attenuated transcriptional responses to osmotic and heavy metal stresses, but not to oxidative stress, and this was reflected in the role of Hog1 in the regulation of C. albicans core stress genes. Instead, the Cap1 transcription factor plays a key role in the oxidative stress regulation of C. albicans core stress genes. Our data show that the SAPK network in C. albicans has diverged from corresponding networks in model yeasts, and that the C. albicans SAPK pathway functions in parallel with other pathways to regulate the core transcriptional response to stress.

{dagger}These authors contributed equally to this study.

||Present Address: Department of Molecular and Cellular Pharmacology, 1580 N.W. 10th Avenue, University of Miami, FL 33136.

Address correspondence to: Alistair J.P. Brown (Al.Brown{at}abdn.ac.uk) or Janet Quinn (janet.quinn{at}ncl.ac.uk)




This article has been cited by other articles:


Home page
 Eukaryot CellHome page
N. Hanaoka, Y. Takano, K. Shibuya, H. Fugo, Y. Uehara, and M. Niimi
Identification of the Putative Protein Phosphatase Gene PTC1 as a Virulence-Related Gene Using a Silkworm Model of Candida albicans Infection
Eukaryot. Cell, October 1, 2008; 7(10): 1640 - 1648.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Biol. CellHome page
M. Ramsdale, L. Selway, D. Stead, J. Walker, Z. Yin, S. M. Nicholls, J. Crowe, E. M. Sheils, and A. J.P. Brown
MNL1 Regulates Weak Acid-induced Stress Responses of the Fungal Pathogen Candida albicans
Mol. Biol. Cell, October 1, 2008; 19(10): 4393 - 4403.
[Abstract] [Full Text] [PDF]

Home page
 Microbiol. Mol. Biol. Rev.Home page
W. L. Chaffin
Candida albicans Cell Wall Proteins
Microbiol. Mol. Biol. Rev., September 1, 2008; 72(3): 495 - 544.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Biol. CellHome page
J. M. Rauceo, J. R. Blankenship, S. Fanning, J. J. Hamaker, J.-S. Deneault, F. J. Smith, A. Nantel, and A. P. Mitchell
Regulation of the Candida albicans Cell Wall Damage Response by Transcription Factor Sko1 and PAS Kinase Psk1
Mol. Biol. Cell, July 1, 2008; 19(7): 2741 - 2751.
[Abstract] [Full Text] [PDF]

Home page
 J Antimicrob ChemotherHome page
S. Hodgetts, L. Nooney, R. Al-Akeel, A. Curry, S. Awad, R. Matthews, and J. Burnie
Efungumab and caspofungin: pre-clinical data supporting synergy
J. Antimicrob. Chemother., May 1, 2008; 61(5): 1132 - 1139.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
C. Mille, P. Bobrowicz, P.-A. Trinel, H. Li, E. Maes, Y. Guerardel, C. Fradin, M. Martinez-Esparza, R. C. Davidson, G. Janbon, et al.
Identification of a New Family of Genes Involved in {beta}-1,2-Mannosylation of Glycans in Pichia pastoris and Candida albicans
J. Biol. Chem., April 11, 2008; 283(15): 9724 - 9736.
[Abstract] [Full Text] [PDF]

Home page
 J Antimicrob ChemotherHome page
C. J. Barelle, V. M. S. Duncan, A. J. P. Brown, N. A. R. Gow, and F. C. Odds
Azole antifungals induce up-regulation of SAP4, SAP5 and SAP6 secreted proteinase genes in filamentous Candida albicans cells in vitro and in vivo
J. Antimicrob. Chemother., February 1, 2008; 61(2): 315 - 322.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Biol. CellHome page
J. Cheetham, D. A. Smith, A. da Silva Dantas, K. S. Doris, M. J. Patterson, C. R. Bruce, and J. Quinn
A Single MAPKKK Regulates the Hog1 MAPK Pathway in the Pathogenic Fungus Candida albicans
Mol. Biol. Cell, November 1, 2007; 18(11): 4603 - 4614.
[Abstract] [Full Text] [PDF]

Home page
 MicrobiologyHome page
R. D. Cannon, E. Lamping, A. R. Holmes, K. Niimi, K. Tanabe, M. Niimi, and B. C. Monk
Candida albicans drug resistance another way to cope with stress
Microbiology, October 1, 2007; 153(10): 3211 - 3217.
[Abstract] [Full Text] [PDF]

Home page
 Eukaryot CellHome page
S. Vylkova, W. S. Jang, W. Li, N. Nayyar, and M. Edgerton
Histatin 5 Initiates Osmotic Stress Response in Candida albicans via Activation of the Hog1 Mitogen-Activated Protein Kinase Pathway
Eukaryot. Cell, October 1, 2007; 6(10): 1876 - 1888.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
B. Enjalbert, D. M. MacCallum, F. C. Odds, and A. J. P. Brown
Niche-Specific Activation of the Oxidative Stress Response by the Pathogenic Fungus Candida albicans
Infect. Immun., May 1, 2007; 75(5): 2143 - 2151.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. ProteomicsHome page
E. Fernandez-Arenas, V. Cabezon, C. Bermejo, J. Arroyo, C. Nombela, R. Diez-Orejas, and C. Gil
Integrated Proteomics and Genomics Strategies Bring New Insight into Candida albicans Response upon Macrophage Interaction
Mol. Cell. Proteomics, March 1, 2007; 6(3): 460 - 478.
[Abstract] [Full Text] [PDF]

Home page
 Eukaryot CellHome page
U. Oberholzer, A. Nantel, J. Berman, and M. Whiteway
Transcript Profiles of Candida albicans Cortical Actin Patch Mutants Reflect Their Cellular Defects: Contribution of the Hog1p and Mkc1p Signaling Pathways.
Eukaryot. Cell, August 1, 2006; 5(8): 1252 - 1265.
[Abstract] [Full Text] [PDF]


Home Help [Feedback] [For Subscribers] [Archive] [Search] --
Copyright © 2005 by The American Society for Cell Biology. Terms of copyright protection, warranties, and disclaimers.