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MBC in Press, published online ahead of print October 5, 2005
Mol. Biol. Cell 10.1091/mbc.E05-07-0617

A more recent version of this article appeared on December 1, 2005
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Submitted on July 12, 2005
Revised on September 6, 2005
Accepted on September 22, 2005

The Aspergillus fumigatus StuA Protein Governs the Upregulation of a Discrete Transcriptional Program during the Acquisition of Developmental Competence

Donald C. Sheppard,* Thomas Doedt,{dagger} Lisa Y. Chiang,{dagger} H. Stanley Kim,{ddagger} Dan Chen,{ddagger} William C. Nierman,{ddagger}{sect} and Scott G. Filler{dagger}

*Departments of Microbiology and Immunology and Medicine, McGill University, Montreal, Quebec H3A 2B4, Canada; {dagger}Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA 90502; {ddagger}The Institute for Genomic Research, Rockville, MD 20850; {sect}Department of Biochemistry and Molecular Biology, George Washington University School of Medicine, Washington, DC 20037

Monitoring Editor: Trisha Davis

Members of the APSES family of fungal proteins regulate morphogenesis and virulence in ascomycetes. We cloned the Aspergillus fumigatus APSES gene encoding StuAp and demonstrated that stuA transcription is markedly up-regulated after the acquisition of developmental competence. A. fumigatus {Delta}stuA mutants were impaired in their ability to undergo asexual reproduction. Conidiophore morphology was markedly abnormal, and only small numbers of dysmorphic conidia were produced, which exhibited precocious germination. Whole genome transcriptional analysis during the onset of developmental competence was performed and identified a subset of developmentally regulated genes that were stuA-dependent, including: a cluster of putative secondary metabolite biosynthesis genes, genes encoding proteins implicated in the regulation of morphogenesis, and genes encoding allergens and other antigenic proteins. Additionally, hyphae of the {Delta}stuA mutant displayed reduced expression of the catalase gene CAT1 and were hyper-susceptible to hydrogen peroxide.

Address correspondence to: Donald C. Sheppard (donald.sheppard{at}mcgill.ca)




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