![[Feedback]](/icons/banner/feedbackACT.gif){kind=icon}
![[For Subscribers]](/icons/banner/subscriberACT.gif){kind=icon}
![[Archive]](/icons/banner/archiveACT.gif){kind=icon}
![[Search]](/icons/banner/searchACT.gif){kind=icon}
|
|
|
|
|
||
A more recent version of this article appeared on April 1, 2006
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Submitted on November 30, 2005
Revised on February 2, 2006
Accepted on February 3, 2006
Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, United Kingdom
Monitoring Editor: Tim Stearns
Kinesin superfamily proteins are ubiquitous to all eukaryotes and essential for several key cellular processes. With the establishment of genome sequence data for a substantial number of eukaryotes, it is now possible for the first time to analyze the complete kinesin repertoires of diverse of organisms from most eukaryotic kingdoms. Such a ‘holistic’ approach using 486 kinesin-like sequences from 19 eukaryotes and analyzed by Bayesian techniques, identifies 3 new kinesin families, 2 new phylum-specific groups and unites 2 previously identified families. The paralog distribution suggests that the eukaryotic cenancestor possessed nearly all kinesin families. However, multiple losses in individual lineages mean that no family is ubiquitous to all organisms and that the present day distribution reflects common biology more than it does common ancestry. In particular, the distribution of 4 families -Kinesin-2, -9 and the proposed new families Kinesin-16 and -17 -correlates with the possession of cilia/flagella, and this can be used to predict a flagellar function for 2 new kinesin families. Finally, we present a set of hidden Markov models that can reliably place most new kinesin sequences into families, even when from an organism at a great evolutionary distance from those in the analysis.
This article has been cited by other articles:
|
|
 |
|
  J. C. Hoeng, S. C. Dawson, S. A. House, M. S. Sagolla, J. K. Pham, J. J. Mancuso, J. Lowe, and W. Z. Cande High-Resolution Crystal Structure and In Vivo Function of a Kinesin-2 Homologue in Giardia intestinalis Mol. Biol. Cell, July 1, 2008; 19(7): 3124 - 3137. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. M. Scholey Intraflagellar transport motors in cilia: moving along the cell's antenna J. Cell Biol., January 10, 2008; 180(1): 23 - 29. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. V. Barkus, O. Klyachko, D. Horiuchi, B. J. Dickson, and W. M. Saxton Identification of an Axonal Kinesin-3 Motor for Fast Anterograde Vesicle Transport that Facilitates Retrograde Transport of Neuropeptides Mol. Biol. Cell, January 1, 2008; 19(1): 274 - 283. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. C. Dawson, M. S. Sagolla, J. J. Mancuso, D. J. Woessner, S. A. House, L. Fritz-Laylin, and W. Z. Cande Kinesin-13 Regulates Flagellar, Interphase, and Mitotic Microtubule Dynamics in Giardia intestinalis Eukaryot. Cell, December 1, 2007; 6(12): 2354 - 2364. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Hou, H. Qin, J. A. Follit, G. J. Pazour, J. L. Rosenbaum, and G. B. Witman Functional analysis of an individual IFT protein: IFT46 is required for transport of outer dynein arms into flagella J. Cell Biol., February 26, 2007; 176(5): 653 - 665. [Abstract] [Full Text] [PDF]
|
|
