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MBC in Press, published online ahead of print September 13, 2006
Mol. Biol. Cell 10.1091/mbc.E06-04-0365

A more recent version of this article appeared on November 1, 2006
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Submitted on April 28, 2006
Revised on August 15, 2006
Accepted on September 1, 2006

Mechanically-induced Actin-mediated Rocketing of Phagosomes

Margaret Clarke,* Annette Müller-Taubenberger,{dagger}{ddagger} Kurt I. Anderson,{sect} Ulrike Engel,|| and Günther Gerisch{dagger}

*Program in Molecular, Cell, and Developmental Biology, Oklahoma Medical Research Foundation, Oklahoma City, OK 73121; {dagger}Max-Planck-Institut für Biochemie, 82152 Martinsried, Germany; {sect}Max-Planck-Institut of Molecular Cell Biology and Genetics, 01037 Dresden, Germany; ||University of Heidelberg, Nikon Imaging Center, 69120 Heidelberg, Germany

Monitoring Editor: David Drubin

Actin polymerization can be induced in Dictyostelium by compressing the cells to bring phagosomes filled with large particles into contact with the plasma membrane. Asymmetric actin assembly results in rocketing movement of the phagosomes. We show that the compression-induced assembly of actin at the cytoplasmic face of the plasma membrane involves the Arp2/3 complex. We also identify two other proteins associated with the mechanically-induced actin assembly. The class I myosin MyoB accumulates at the plasma membrane-phagosome interface early during the initiation of the response, and coronin is recruited as the actin filaments are disassembling. The forces generated by rocketing phagosomes are sufficient to push the entire microtubule apparatus forward and to dislocate the nucleus.

{ddagger}Present address: Institute for Cell Biology (ABI), Ludwig Maximilians University Munich, 80336 München, Germany.

Address correspondence to: Margaret Clarke (clarkem{at}omrf.ouhsc.edu)




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[Abstract] [Full Text] [PDF]


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