Molecular Biology of the Cell Call for Nominations: MBC Editor-in-Chief

Home Help [Feedback] [For Subscribers] [Archive] [Search] --
QUICK SEARCH:   [advanced]


     

MBC in Press, published online ahead of print February 7, 2007
Mol. Biol. Cell 10.1091/mbc.E06-08-0693

A more recent version of this article appeared on April 1, 2007
This Article
Right arrow Full Text (PDF)
Right arrow Supplemental Material
Right arrow All Versions of this Article:
E06-08-0693v1
18/4/1397    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Christov, C.
Right arrow Articles by Gherardi, R. K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Christov, C.
Right arrow Articles by Gherardi, R. K.

Submitted on August 9, 2006
Revised on December 22, 2006
Accepted on January 30, 2007

Muscle Satellite Cells and Endothelial Cells: Close Neighbors and Privileged Partners

Christo Christov,*{dagger}{ddagger}{sect}|| Fabrice Chrétien,*{dagger}{ddagger}||¶ Rana Abou Khalil,*{dagger}{ddagger} Guillaume Bassez,*{dagger}{ddagger} Grégoire Vallet,*{dagger}{ddagger} François-Jérôme Authier,*{dagger}{ddagger} Yann Bassaglia,*{dagger}{ddagger} Vasily Shinin,¶ Shahragim Tajbakhsh,¶ Bénédicte Chazaud,*{dagger}{ddagger} and Romain K. Gherardi*{dagger}{ddagger}{sect}

*INSERM, Unité 841, IMRB, Team N°10, Créteil, F-94000, France; {dagger}Université Paris XII-Val de Marne, Créteil, F-94000, France; {ddagger}Service d’Histologie, Département de Pathologie, Hôpital Henri Mondor, Assistance Publique-Hôpitaux de Paris, F-94000 Créteil, France; {sect}"PICTURES" Cell and Tissue Imaging Unit of Institut Mondor de Médecine Moléculaire, IFR 10, Créteil, F-94000, France; "Stem Cells and Development", Department of Developmental Biology, Pasteur Institute, Paris, F-75015, France
*INSERM, Unité 841, IMRB, Team N°10, Créteil, F-94000, France; {dagger}Université Paris XII-Val de Marne, Créteil, F-94000, France; {ddagger}Service d’Histologie, Département de Pathologie, Hôpital Henri Mondor, Assistance Publique-Hôpitaux de Paris, F-94000 Créteil, France; {sect}"PICTURES" cell and tissue imaging unit of Institut Mondor de Médecine Moléculaire, IFR 10, Créteil, F-94000, France; "Stem Cells and Development", Department of Developmental Biology, Pasteur Institute, Paris, F-75015, France

Monitoring Editor: Marianne Bronner-Fraser

Genetically engineered mice (Myf5nLacZ/+, Myf5GFP-P/+) allowing direct muscle satellite cell (SC) visualization indicate that, in addition to being located beneath myofiber basal laminae, SCs are strikingly close to capillaries. After GFP+ bone marrow transplantation, blood-borne cells occupying SC niches previously depleted by irradiation, were similarly detected near vessels, thereby corroborating the anatomical stability of juxtavascular SC niches. BrdU pulse-chase experiments also localize quiescent and less quiescent SCs near vessels. SCs, and to a lesser extent myonuclei, were nonrandomly associated with capillaries in humans. Significantly, they were correlated with capillarisation of myofibers, regardless to their type, in normal muscle. They also varied in paradigmatic physiological and pathological situations associated with variations of capillary density, including amyopathic dermatomyositis, a unique condition in which muscle capillary loss occurs without myofiber damage, and in athletes, in whom capillaries increase in number. Endothelial cell (EC) cultures specifically enhanced SC growth, through IGF-1, HGF, bFGF, PDGF-BB and VEGF, and, accordingly, cycling SCs remained mainly juxtavascular. Conversely, differentiating myogenic cells were both proangiogenic in vitro and spatiotemporally associated with neoangiogenesis in muscular dystrophy. Thus, SCs are largely juxtavascular and reciprocally interact with ECs during differentiation to support angio-myogenesis.

||These authors contributed equally to this work.

Address correspondence to: Romain K. Gherardi (romain.gherardi{at}hmn.aphp.fr)




This article has been cited by other articles:


Home page
 J Am Coll CardiolHome page
M. Okada, T. R. Payne, B. Zheng, H. Oshima, N. Momoi, K. Tobita, B. B. Keller, J. A. Phillippi, B. Peault, and J. Huard
Myogenic Endothelial Cells Purified From Human Skeletal Muscle Improve Cardiac Function After Transplantation Into Infarcted Myocardium
J. Am. Coll. Cardiol., December 2, 2008; 52(23): 1869 - 1880.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
P. S. Zammit
All muscle satellite cells are equal, but are some more equal than others?
J. Cell Sci., September 15, 2008; 121(18): 2975 - 2982.
[Abstract] [Full Text] [PDF]

Home page
 J. Histochem. Cytochem.Home page
M. Z. Allouh, Z. Yablonka-Reuveni, and B. W.C. Rosser
Pax7 Reveals a Greater Frequency and Concentration of Satellite Cells at the Ends of Growing Skeletal Muscle Fibers
J. Histochem. Cytochem., January 1, 2008; 56(1): 77 - 87.
[Abstract] [Full Text] [PDF]


Home Help [Feedback] [For Subscribers] [Archive] [Search] --
Copyright © 2007 by The American Society for Cell Biology. Terms of copyright protection, warranties, and disclaimers.