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MBC in Press, published online ahead of print October 3, 2007
Mol. Biol. Cell 10.1091/mbc.E07-03-0243

A more recent version of this article appeared on December 1, 2007
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Submitted on March 22, 2007
Revised on September 19, 2007
Accepted on September 25, 2007

Caenorhabditis elegans prom-1 Is Required for Meiotic Prophase Progression and Homologous Chromosome Pairing

Verena Jantsch,* Lois Tang,* Pawel Pasierbek,{dagger} Alexandra Penkner,* Sudhir Nayak,{ddagger} Antoine Baudrimont,* Tim Schedl,{ddagger} Anton Gartner,{sect} and Josef Loidl*

*Department of Chromosome Biology and Max F. Perutz Laboratories, Faculty of Life Sciences, University of Vienna, A-1030 Vienna, Austria; {dagger}Biooptics Department, Research Institute of Molecular Pathology (IMP), A-1030 Vienna, Austria; {ddagger}Department of Genetics, Washington University School of Medicine, St. Louis, MO 63110; {sect}School of Life Sciences, University of Dundee, Dundee DD1 5EH, United Kingdom

Monitoring Editor: Yixian Zheng

A novel gene, prom-1, was isolated in a screen for C. elegans mutants with increased apoptosis in the germline. prom-1 encodes an F-box protein with limited homology to the putative human tumor suppressor FBXO47. Mutations in the prom-1 locus cause a strong reduction in bivalent formation, which results in increased embryonic lethality and a Him phenotype. Furthermore, retarded and asynchronous nuclear reorganization as well as reduced homologous synapsis occur during meiotic prophase. Accumulation of recombination protein RAD-51 in meiotic nuclei suggests disturbed repair of double-stranded DNA breaks. Nuclei in prom-1 mutant gonads timely complete mitotic proliferation and premeiotic replication but undergo prolonged delay upon meiotic entry. We, therefore, propose that prom-1 regulates the timely progression through meiotic prophase I and that in its absence the recognition of homologous chromosomes is strongly impaired.

Address correspondence to: Josef Loidl (josef.loidl{at}univie.ac.at)






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