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MBC in Press, published online ahead of print July 18, 2007
Mol. Biol. Cell 10.1091/mbc.E07-03-0263

A more recent version of this article appeared on October 1, 2007
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Submitted on March 21, 2007
Revised on July 3, 2007
Accepted on July 10, 2007

putzig Is Required for Cell Proliferation and Regulates Notch Activity in Drosophila

Sabrina J. Kugler and Anja C. Nagel

Institute of Genetics (240), University of Hohenheim, 70599 Stuttgart, Germany

Monitoring Editor: Carl-Henrik Heldin

We have identified the gene putzig (pzg) as a key regulator of cell proliferation and of Notch signaling in Drosophila. pzg encodes a Zn-finger protein that was found earlier within a macromolecular complex including TRF2/DREF. This complex is involved in core promoter selection, where DREF functions as a transcriptional activator of replication-related genes. Here, we provide the first in vivo evidence that pzg is required for the expression of cell cycle and replication-related genes, and hence for normal developmental growth. Independent of its role in the TRF2/DREF complex, pzg acts as a positive regulator of Notch signaling which may occur by chromatin activation. Down-regulation of pzg activity inhibits Notch target gene activation, whereas Hh signal transduction and growth regulation is unaffected. Our findings uncover different modes of operation of pzg during imaginal development of Drosophila and provide a novel mechanism of Notch regulation.

Address correspondence to: Anja C. Nagel (anjnagel{at}uni-hohenheim.de)






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