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MBC in Press, published online ahead of print January 9, 2008
Mol. Biol. Cell 10.1091/mbc.E07-06-0584

A more recent version of this article appeared on March 1, 2008 Originally published as MBC in Press, 10.1091/mbc.E07-06-0584 on December 19, 2007
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Submitted on June 19, 2007
Revised on October 29, 2007
Accepted on December 12, 2007

Shugoshin Promotes Sister Kinetochore Bi-Orientation in Saccharomyces cerevisiae

Brendan M. Kiburz,* Angelika Amon,* and Adele L. Marston{dagger}

*Center for Cancer Research, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139; {dagger}The Wellcome Trust Centre for Cell Biology, School of Biological Sciences, University of Edinburgh, Edinburgh, EH9 3JR, United Kingdom

Monitoring Editor: Orna Cohen-Fix

Chromosome segregation must be executed accurately during both mitotic and meiotic cell divisions. Sgo1 plays a key role in ensuring faithful chromosome segregation in at least two ways. During meiosis this protein regulates the removal of cohesins, the proteins that hold sister chromatids together, from chromosomes. During mitosis, Sgo1 is required for sensing the absence of tension caused by sister kinetochores not being attached to microtubules emanating from opposite poles. Here we describe a differential requirement for Sgo1 in the segregation of homologous chromosomes and sister chromatids. Sgo1 plays only a minor role in segregating homologous chromosomes at meiosis I. In contrast, Sgo1 is important to bias sister kinetochores toward biorientation. We suggest that Sgo1 acts at sister kinetochores to promote their biorientation.

Address correspondence to: Adele L. Marston (adele.marston{at}ed.ac.uk)






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