Molecular Biology of the Cell Call for Nominations: MBC Editor-in-Chief

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

Originally published as MBC in Press, 10.1091/mbc.E06-07-0634 on September 27, 2006

Vol. 17, Issue 12, 5241-5252, December 2006

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Supplemental Material
Right arrow All Versions of this Article:
E06-07-0634v1
17/12/5241    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Wong, J. L.
Right arrow Articles by Wessel, G. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Wong, J. L.
Right arrow Articles by Wessel, G. M.

Rendezvin: An Essential Gene Encoding Independent, Differentially Secreted Egg Proteins That Organize the Fertilization Envelope Proteome after Self-AssociationFormula

Julian L. Wong, and Gary M. Wessel

Department of Molecular Biology, Cellular Biology, and Biochemistry, Brown University, Providence, RI 02912

Submitted July 25, 2006; Revised September 11, 2006; Accepted September 18, 2006
Monitoring Editor: Marianne Bronner-Fraser

Preventing polyspermy during animal fertilization relies on modifications to the egg's extracellular matrix. On fertilization in sea urchins, the contents of cortical granules are secreted and rapidly assemble into the egg's extracellular vitelline layer, forming the fertilization envelope, a proteinaceous structure that protects the zygote from subsequent sperm. Here, we document rendezvin, a gene whose transcript is differentially spliced to yield proteins destined for either cortical granules or the vitelline layer. These distinctly trafficked variants reunite after cortical granule secretion at fertilization. Together, they help coordinate assembly of the functional fertilization envelope, whose proteome is now defined in full.

Formula The online version of this contains supplemental material at MBC Online (http://www.molbiolcell.org).

This article was published online ahead of print in MBC in Press (http://www.molbiolcell.org/cgi/doi/10.1091/mbc.E06-07-0634) on September 27, 2006.

Address correspondence to: Gary M. Wessel (rhet{at}brown.edu)

Abbreviations used: CG, cortical granule; FE, fertilization envelope; RDZ, rendezvin; VL, vitelline layer.




This article has been cited by other articles:


Home page
 DevelopmentHome page
J. L. Wong and G. M. Wessel
Free-radical crosslinking of specific proteins alters the function of the egg extracellular matrix at fertilization
Development, February 1, 2008; 135(3): 431 - 440.
[Abstract] [Full Text] [PDF]


Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
Copyright © 2006 by The American Society for Cell Biology. Terms of copyright protection, warranties, and disclaimers.