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Originally published as MBC in Press, 10.1091/mbc.E07-07-0682 on October 31, 2007

Vol. 19, Issue 1, 78-85, January 2008

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S100A11, an Dual Mediator for Growth Regulation of Human Keratinocytes

Masakiyo Sakaguchi*, Hiroyuki Sonegawa*, Hitoshi Murata*,{dagger}, Midori Kitazoe{dagger}, Jun-ichiro Futami{dagger}, Ken Kataoka*, Hidenori Yamada{dagger}, and Nam-ho Huh*

*Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Shikatachou, Okayama 700-8558, Japan; and {dagger}Department of Bioscience and Biotechnology, Okayama University Graduate School of Natural Science and Technology, Tsushimanaka, Okayama 700-8530, Japan

Submitted July 19, 2007; Revised October 10, 2007; Accepted October 18, 2007
Monitoring Editor: M. Bishr Omary

We previously revealed a novel signal pathway involving S100A11 for inhibition of the growth of normal human keratinocytes (NHK) caused by high Ca++ or transforming growth factor β. Exposure to either agent resulted in transfer of S100A11 to nuclei, where it induced p21WAF1. In contrast, S100A11 has been shown to be overexpressed in many human cancers. To address this apparent discrepancy, we analyzed possible new functions of S100A11, and we provide herein evidence that 1) S100A11 is actively secreted by NHK; 2) extracellular S100A11 acts on NHK to enhance the production of epidermal growth factor family proteins, resulting in growth stimulation; 3) receptor for advanced glycation end products, nuclear factor-{kappa}B, Akt, and cAMP response element-binding protein are involved in the S100A11-triggered signal transduction; and 4) production and secretion of S100A11 are markedly enhanced in human squamous cancer cells. These findings indicate that S100A11 plays a dual role in growth regulation of epithelial cells.

This was published online ahead of print in MBC in Press (http://www.molbiolcell.org/cgi/doi/10.1091/mbc.E07-07-0682) on October 31, 2007.

Address correspondence to: Nam-ho Huh (namu{at}md.okayama-u.ac.jp)

Abbreviations used: NHK, normal human keratinocytes; RAGE, receptor for advanced glycation end products.




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