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Originally published as MBC in Press, 10.1091/mbc.E07-09-0930 on March 5, 2008

Vol. 19, Issue 5, 2051-2058, May 2008

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Collagen Fibril Flow and Tissue Translocation Coupled to Fibroblast Migration in 3D Collagen Matrices

Miguel Miron-Mendoza, Joachim Seemann, and Frederick Grinnell

Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390-9039

Submitted September 18, 2007; Revised February 6, 2008; Accepted February 19, 2008
Monitoring Editor: Yu-Li Wang

In nested collagen matrices, human fibroblasts migrate from cell-containing dermal equivalents into surrounding cell-free outer matrices. Time-lapse microscopy showed that in addition to cell migration, collagen fibril flow occurred in the outer matrix toward the interface with the dermal equivalent. Features of this flow suggested that it depends on the same cell motile machinery that normally results in cell migration. Collagen fibril flow was capable of producing large-scale tissue translocation as shown by closure of a ~1-mm gap between paired dermal equivalents in floating, nested collagen matrices. Our findings demonstrate that when fibroblasts interact with collagen matrices, tractional force exerted by the cells can couple to matrix translocation as well as to cell migration.

This was published online ahead of print in MBC in Press (http://www.molbiolcell.org/cgi/doi/10.1091/mbc.E07-09-0930) on March 5, 2008.

Address correspondence to: Frederick Grinnell (frederick.grinnell{at}utsouthwestern.edu)




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