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Cover  The ability of cells to migrate into a wounded monolayer is well known and is thought to reflect the behavior of cell populations in situ. This month's cover art by William Arthur and Keith Burridge (University of North Carolina, Chapel Hill, NC) shows rat fibroblasts migrating into a wounded area. Cells were stained with Hoechst 33342, Texas-Red-Phalloidin, and Golgi-specific antibodies to reveal nuclei (blue), F-actin (red), and Golgi (green), respectively. An important feature of the migrating cells is their polarity. This is seen in the selective protrusion of lamellipodia and filopodia toward the leading edge facing the wound and the suppression of lateral protrusions. In addition, the Golgi apparatus and nearby centriole are reoriented to the region in front of the nucleus in the direction of migration. The signaling pathways that are initiated upon wounding a monolayer that gives rise to this polarized phenotype are currently of great interest to cell biologists. By monitoring the movement of cells into a wounded monolayer by the above fluorescence microscopic approach, Arthur and Burridge (Mol. Biol. Cell [2001]. 12, 2711-2720) have recently shown that expression of dominant negative p190RhoGAP inhibits polarity in the direction of migration. This suggests that integrin-triggered RhoA inhibition may underlie spreading and migration during the wound healing process.Jennifer Lippincott-Schwartz