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Neurons from the nematode C. elegans are shown expressing a GFP-tagged UNC-104 kinesin motor protein that is involved in synaptic vesicle transport (round cell bodies and thin axonal processes are shown in green). Superimposed are tracks made by C. elegans moving across an agar plate. As described by Klopfenstein et al. (Mol. Biol. Cell [2004], 15, 3729-3739), a lipid-binding, pleckstrin homology domain in UNC-104 is necessary for synaptic vesicle transport and for normal animal locomotion.

-Dieter Klopfenstein