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Human skin section, stained with an N-terminally directed Nesprin-2 antibody (red) and FITC-conjugated phalloidin (green). Nesprin-2 is an 800-kDa dystrophinlike protein that localizes in a lamin A/C-dependent manner to both sites of the nuclear envelope. The LMNA locus codes for lamin A, lamin C, lamin AΔ10, and the testis-specific lamin C2, which are generated through alternative splicing. Lamins A and C differ in that lamin A possesses an additional 90 amino acids at its C terminus. Skin is a stratified epithelium, where the lamin A and lamin C isoforms are differentially expressed. In contrast to lamin C, which is present in all layers of the epidermis, including the basal layer, lamin A is found only in a few suprabasal epithelial cells and dermal fibroblasts. In this image, Nesprin-2 staining is present in all living layers of the epidermis, localizing to the nuclei of the epithelial cells, including the basal layer. Thus, in human skin, lamin C is sufficient for proper Nesprin-2 localization at the nuclear envelope. See the article by Libotte et al. on p. 3411 of the July 2005 issue of MBC. (Image: Iakowos Karakesisoglou and V. C. Padmakumar, University of Cologne)

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Copyright © 2005 by The American Society for Cell Biology.