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Early anaphase HeLa cell expressing green fluorescent protein-CLASP2 (green), which localizes at kinetochores and centrosomes. Spindle microtubules are shown in red, and chromosomes are shown in blue. CLASPs are widely conserved microtubule plus-end tracking proteins and, in mammals, are encoded by two paralogue genes--clasp1 and clasp2--which play partially redundant roles during mitosis. Analysis of primary cells derived from Clasp2 knockout mice indicates that Clasp2 per se plays important roles in spindle and kinetochore function, especially during anaphase. Overall, CLASPs play cooperative roles that ensure mitotic fidelity and prevent aneuploidy in mammals. For more information, see the full article by Pereira et al. on p. 4526 in this issue of MBC. (Image: Helder Maiato, Instituto de Biologia Molecular e Celular, University of Porto, Porto, Portugal)

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