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A Src-transformed NIH3T3 cell analyzed by immunofluorescence for localization of F-actin (blue), phosphotyrosine (green), and RhoGDI (red). RhoGDI that has been tyrosine-phosphorylated by Src, unlike the nonphosphorylated RhoGDI, becomes localized to cytoskeletal structures, such as podosomes/rosettes, that are involved in cell invasion. See the full article by DerMardirossian et al. on p. 4760 of this issue of MBC. (Image: Céline DerMardirossian, Department of Immunology, The Scripps Research Institute, La Jolla, CA)

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