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Function reflected in form. Arp10 from budding yeast is the homolog of metazoan Arp11. It caps the pointed end of the Arp1 filament (right end) and stabilizes the association of another dynactin subunit, Jnm1/dynamitin (not shown), with the Arp1 filament. Mutational analysis of Arp1 revealed two mutations on the pointed end of Arp1 that suggest Arp10 associates with both of the adjacent Arp1 monomers. Arp10 is represented as a blue monomer of Arp1 with those residues deleted with respect to Arp1 shown in red and the points of small insertions shown in yellow. The position of Arp10's deletions on the pointed-end face of the subunit provides a mechanism for function as a capping protein, preventing further elongation of the Arp1 filament. See the full article by Clark and Rose on p. 738 in this issue of MBC. (Image: Sean Clark, Princeton University)

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