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Microscopic image of a section from a 10-day-old mouse cerebellum. The Purkinje cells are stained red with antibodies that are specific for an alternatively spliced isoform of nonmuscle myosin II-B that is found only in certain neuronal cells. The glial cells of the cerebellum are stained green with antibodies labeling the glial fibrillar acidic protein. The figure shows that this particular isoform of nonmuscle myosin II-B is found only in the Purkinje cells in the cerebellum. Mice in which this isoform of nonmuscle myosin II-B has been genetically ablated have abnormal Purkinje cells and impaired motor activity. See the full article by Ma et al. on p. 2138 in this issue of MBC. (Image: Xuefei Ma, National Heart, Lung, and Blood Institute/National Institutes of Health).

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