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Dynamic behavior of podosomal adhesions in primary human macrophages. Larger image, analysis of podosome dynamics. Podosomes are color-coded according to their behavior: fission (green), dissolution (red), or static (blue). In the cell periphery, larger podosome structures mostly undergo fission, and smaller podosomes mostly dissolve, while small, static podosomes cluster in the cell center. Inset, dynamic behavior of podosomes is often preceded by contact with microtubule plus ends. In this confocal laser scanning micrograph of the ventral, substrate-attached part of a macrophage, podosome cores are labeled by expression of monomeric red fluorescent protein-β-actin (red), and microtubule plus ends are highlighted by green fluorescent protein-cytoplasmic linker protein 170 (green). Image sizes are approximately 80 µm. See the full article by Kopp et al. on p. 2811 in this issue of MBC. (Images: Petra Kopp and Stefan Linder, Institute for Cardiovascular Diseases, LMU, Munich, Germany)

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Copyright © 2006 by The American Society for Cell Biology.