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Mistargeting of the prion protein (PrP) to the cytosolic compartment induces apoptosis, which is visualized by staining of activated caspase-3 (outer image, blue). The central images show the localization of the anti-apoptotic protein Bcl-2 depending on the expression of cytosolic PrP (cytoPrP). The physiological localization of Bcl-2 (green) at the ER, mitochondria, and nuclear envelope is seen in the upper left cell. In the lower right cell, coexpressed cytoPrP (red) colocalizes with Bcl-2 and induces its aggregation (merge, yellow). A compartment-specific toxicity of PrP in the cytosol involves binding of PrP to Bcl-2 and appears to interfere with the anti-apoptotic potential of Bcl-2. See the full article by Rambold et al. on p. 3356 in this issue of MBC. (Image: Angelika Rambold, Adolf-Butenandt-Institut, Neurobiochemistry, Ludwig-Maximilians-University, Munich, Germany)

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