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A rat hippocampal neuron expressing shRNA for neurabin I, an F-actin binding scaffold protein that is normally highly expressed in differentiating neurons. Successful targeting of the neuron is marked by EGFP expression (green). Actin filaments are shown in red and neuron-specific β-III tubulin in blue. Loss of neurabin I caused the neuron to adopt a splayed morphology with severely shortened neurites and no discernable axon. The authors conclude that neurabin I is required for cytoskeletal modifications that underlie normal neuronal differentiation. See the article by Causeret et al. on p. 4327 of this issue of MBC. (Image: Frédéric Causeret and Margareta Nikolić , Imperial College London)