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A COS7 cell (left) expressing a GIT1 mutant lacking the three ankyrin repeats (in red) shows reduced spreading on fibronectin and reduced paxillin-positive focal adhesions (in green) compared to a nontransfected cell (right). GIT1 regulates adhesion and motility. The interaction of endogenous paxillin with the “activated” GIT1 mutant results in paxillin mislocalization and inhibition of cell spreading. See the article by Totaro et al. on p. 5124 of this issue of MBC. (Image: Antonio Totaro, San Raffaele Scientific Institute, Milano, Italy)