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Many integral membrane proteins targeted for degradation in eukaryotic cells are sorted into the lumenal vesicles of multivesicular endosomes en route to being deposited into lysosomes. The cover image is derived from electron tomography of Saccharomyces cerevisiae and shows delivery of endosomal lumenal vesicles (blue) into vacuoles (red), which are lysosome-like organelles in yeast. Also shown are multivesicular endosomes (yellow) that have yet to fuse with vacuoles, as well as a mitochondrion (green) and a portion of the endoplasmic reticulum studded with ribosomes (purple). See the full article by McNatt et al. on p. 697 in this issue of MBC. (Image: Matthew West, University of Colorado, Boulder, CO)

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