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A three-dimensional model of the γ-tubulin small complex (γ-TuSC), the core component of the microtubule nucleation machinery, determined by single particle reconstruction from electron micrographs is shown against a background of individual two-dimensional images of the complex. γ-Tubulin was localized to the two tips at the top of the Y-shaped structure. The arm shown in light blue is flexibly attached to the rest of the molecule, adopting several conformations with varying distances between γ-tubulins. A modeled oligomer of γ-TuSC is shown in the background, both free and bound at the ends of microtubules. See the article by Kollman et al. on p. 207 of this issue of MBC. (Image: Justin Kollman, Department of Biochemistry and Biophysics, University of California, San Francisco)

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